6-(二氨基亚甲基氨基)己基氨基甲酰甲基N-[4-[[(3R)-3-氨基丁基]氨基]丁基]氨基甲酸酯 | 170368-04-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 6-(二氨基亚甲基氨基)己基氨基甲酰甲基N-[4-[[(3R)-3-氨基丁基]氨基]丁基]氨基甲酸酯
• 中文别名: D-脯氨酸,4-(乙酰氧基)-,反-(9CI)
• 英文名称: Anisperimus
• 英文别名: [2-[6-(diaminomethylideneamino)hexylamino]-2-oxoethyl] N-[4-[[(3R)-3-aminobutyl]amino]butyl]carbamate
• CAS: 170368-04-4
• 化学式: C₁₈H₃₉N₇O₃
• 分子量: 401.5
• InChiKey: PZDPVSFZTKORSP-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  28
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  170
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  tert-butyl N-[(2R)-4-[4-[[2-[6-[bis[(2-methylpropan-2-yl)oxycarbonylamino]methylideneamino]hexylamino]-2-oxoethoxy]carbonylamino]butylamino]butan-2-yl]carbamate 以73的产率得到6-(二氨基亚甲基氨基)己基氨基甲酰甲基N-[4-[[(3R)-3-氨基丁基]氨基]丁基]氨基甲酸酯
  参考文献：
  名称：

  J. Med. Chem. 1999, 42, 4749-4763

  摘要：

  DOI：

文献信息

• Analogues de la 15-déoxyspergualine, leur procédé de préparation et leur utilisation en tant qu'agents immunosuppresseurs
  申请人：FOURNIER INDUSTRIE ET SANTE

  公开号：EP0669316B1

  公开（公告）日：1997-07-30
• Small molecule immunopotentiators and assays for their detection
  申请人：Valiante Nicholas

  公开号：US20110104186A1

  公开（公告）日：2011-05-05

  The invention provides immunostimulatory compositions comprising a small molecule immuno-potentiator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma. In a further aspect, the invention relates generally to methods of screening for small molecule immuno-modulatory compositions.
• IMMUNOTOXIN FUSION PROTEINS AND MEANS FOR EXPRESSION THEREOF
  申请人：Neville, Jr. David M.

  公开号：US20110086416A1

  公开（公告）日：2011-04-14

  The present invention described and shown in the specification and drawings provides novel recombinant DT-based immunotoxins, and, more specifically anti-T cell immunotoxin fusion proteins. Also provided are immunotoxins that can be expressed in bacterial, yeast, or mammalian cells. The invention also provides means for expression of the immunotoxin fusion protein. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
• US7696338B2
  申请人：——

  公开号：US7696338B2

  公开（公告）日：2010-04-13
• US7776829B2
  申请人：——

  公开号：US7776829B2

  公开（公告）日：2010-08-17