(S,E)-2-Amino-5-((amino(methylthio)methylene)amino)pentanoic acid dihydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S,E)-2-Amino-5-((amino(methylthio)methylene)amino)pentanoic acid dihydrochloride
• 英文别名: (2S)-2-amino-5-[[amino(methylsulfanyl)methylidene]amino]pentanoic acid;dihydrochloride
• 化学式: C7H17Cl2N3O2S
• 分子量: 278.2
• InChiKey: JNZHDSKJUXGYRG-XRIGFGBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• Use of methylene blue and related compounds to prevent or reverse an exaggerated hemodynamic reaction
  申请人：——

  公开号：US20030219495A1

  公开（公告）日：2003-11-27

  The present invention relates to the use of the dye methylene blue (MB) or a related compound to prevent or reverse an exaggerated hemodynamic reaction in animals in need thereof, including humans. More specifically, the present invention concerns the use of MB or a related compound to prevent or reverse hypotension, unstable angina, myocardial infarction or shock caused by the concomitant ingestion of a phosphodiesterase inhibitor, such as sildenafil citrate, and a NO-donor, such as L-arginine, or an organic nitrate, such as nitroglycerin.

  本发明涉及亚甲基蓝（MB）染料或相关化合物在有需要的动物（包括人类）中用于预防或逆转夸张的血液动力学反应。更具体地说，本发明涉及甲基溴或相关化合物的用途，以防止或逆转同时摄入磷酸二酯酶抑制剂（如枸橼酸西地那非）和一氧化氮供体（如左旋精氨酸）或有机硝酸盐（如硝酸甘油）引起的低血压、不稳定型心绞痛、心肌梗塞或休克。
• Inhibitors of serine protease activity methods and compositions for treatment of nitric oxide-induced clinical conditions
  申请人：——

  公开号：US20040220113A1

  公开（公告）日：2004-11-04

  A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having a serine protease inhibitory activity. Among effective compounds are &agr; 1 -antitrypsin and synthetic drugs mimicking some or all of the actions of &agr; 1 -antitrypsin.

  本文提供了一种治疗和预防疾病的新方法。特别是，本发明公开了阻断与一氧化氮水平异常相关并由丝氨酸蛋白酶（SP）活性促进的疾病的组合物和方法，其中包括向受试者施用治疗有效量的具有丝氨酸蛋白酶抑制活性的化合物。其中有效的化合物有 1 -抗胰蛋白酶和模拟 &agr; 1 的部分或全部作用的合成药物； 1 -抗胰蛋白酶。
• Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
  申请人：——

  公开号：US20040220242A1

  公开（公告）日：2004-11-04

  A novel method of treating and preventing diseases is provided. In particular, compositions and methods of blocking diseases associated with aberrant levels of nitric oxide and facilitated by a serine proteolytic (SP) activity are disclosed, which consist of administering to a subject a therapeutically effective amount of a compound having a serine protease inhibitory activity. Among effective compounds are &agr; 1 -antitrypsin and synthetic drugs mimicking some or all of the actions of &agr; 1 -antitrypsin.

  本文提供了一种治疗和预防疾病的新方法。特别是，本发明公开了阻断与一氧化氮水平异常相关并由丝氨酸蛋白酶（SP）活性促进的疾病的组合物和方法，其中包括向受试者施用治疗有效量的具有丝氨酸蛋白酶抑制活性的化合物。其中有效的化合物有 1 -抗胰蛋白酶和模拟 &agr; 1 的部分或全部作用的合成药物； 1 -抗胰蛋白酶。
• Method of targeting a therapeutic agent
  申请人：Went T. Gregory

  公开号：US20050124701A1

  公开（公告）日：2005-06-09

  Disclosed are conjugates in which an aminoadamantane derivative, such as amantadine, memantine, or rimantadine is linked to a therapeutic agent. The conjugate can then be used to target the therapeutic agent to an injured neuron.

  本发明公开了一种共轭物，其中的氨基金刚烷衍生物（如金刚烷胺、美金刚胺或利金刚烷胺）与一种治疗剂相连接。该共轭物可用于将治疗剂靶向损伤的神经元。
• USE OF METHYLENE BLUE AND RELATED COMPOUNDS TO PREVENT OR REVERSE AN EXAGGERATED HEMODYNAMIC REACTION
  申请人：Institut de Cardiologie de Montreal

  公开号：EP1494677A1

  公开（公告）日：2005-01-12