[(2R,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] 4-oxopentanoate | 1150314-65-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: [(2R,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] 4-oxopentanoate
• CAS: 1150314-65-0
• 化学式: C₁₅H₂₀N₂O₇
• 分子量: 340.333
• InChiKey: DSXAZYNMJFDPHQ-IJLUTSLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  [(2R,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] 4-oxopentanoate 、 cyclo-3,5-di(tert-butyl)-6-fluoro chlorophosphite 在 N,N-二异丙基乙胺 、 叔丁基过氧化氢 作用下， 以 四氢呋喃 为溶剂， 生成 (2R,3R,5R)-2-(((6,8-di-tert-butyl-5-fluoro-2-oxido-4H-benzo[d][1,3,2]dioxaphosphinin-2-yl)oxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl 4-oxopentanoate
  参考文献：
  名称：

  Radiologic Agents for Monitoring Alzheimer's Disease Progression and Evaluating a Response to Therapy and Processes for the Preparation of Such Agents

  摘要：

  本文披露了包含正电子发射体或伽马辐射放射性卤化物的某些环丝氨基嘧啶核苷酸单磷酸盐，其用于监测阿尔茨海默病的进展并评估对治疗的反应，以及它们的制备过程。

  公开号：

  US20090117041A1
• 作为产物：
  描述：

  levulinoyl(-3)[DMT(-5)]2-deoxy-D-thrPenf(b)-thymin-1-yl 在 氯化锆(IV) 作用下， 以 乙腈 为溶剂， 生成 [(2R,3R,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl] 4-oxopentanoate
  参考文献：
  名称：

  Radiologic Agents for Monitoring Alzheimer's Disease Progression and Evaluating a Response to Therapy and Processes for the Preparation of Such Agents

  摘要：

  本文披露了包含正电子发射体或伽马辐射放射性卤化物的某些环丝氨基嘧啶核苷酸单磷酸盐，其用于监测阿尔茨海默病的进展并评估对治疗的反应，以及它们的制备过程。

  公开号：

  US20090117041A1

文献信息

• SULFURIZATION REAGENTS ON SOLID SUPPORTS
  申请人：Mazur Wieslaw Adam

  公开号：US20140179875A1

  公开（公告）日：2014-06-26

  Described herein are novel solid-supported sulfurization reagents having the general structure: (I) wherein (P) is a polymer; X is a linker; R 1 is an alkyl group, a cycloalkyl group, an aryl group, or a heterocycle; and R 2 is an alkyl group, an aryl group, a methyleneacyloxy group having the formula —CH 2 —O—C(O)—R 7 , a methylene carbonate group having the formula —CH 2 —O—C(O)—OR 8 , or a methylene carbamate group having the formula —CH 2 —O—C(O)—NR 9 R 10 , wherein R 7 is a C 1 to C 20 hydrocarbon residue, R 8 is any alkyl, cycloalkyl, aryl, or heteroaryl, and R 9 and R 10 are independently hydrogen, alkyl, cycloalkyl, aryl, or heteroaryl. Other embodiments include solid-supported sulfurization reagents having the structure of Formula I, wherein (P) is a polystyrene-based solid support and X is an aromatic linker. Also described herein are methods for synthesizing the solid-supported sulfurization reagents and their use during the synthesis of oligonucleotides.

  本文描述了一种新型固体支持硫化试剂，其具有以下通用结构：(I)，其中(P)是聚合物；X是连接剂；R1是烷基、环烷基、芳基或杂环基；R2是烷基、芳基、具有公式—CH2—O—C(O)—R7的亚甲基酰氧基、具有公式—CH2—O—C(O)—OR8的亚甲基碳酸基或具有公式—CH2—O—C(O)—NR9R10的亚甲基氨基甲酸酯基，其中R7是C1到C20碳氢残基，R8是任何烷基、环烷基、芳基或杂芳基，R9和R10独立地为氢、烷基、环烷基、芳基或杂芳基。其他实施例包括具有式I结构的固体支持硫化试剂，其中(P)是基于聚苯乙烯的固体支持，X是芳香连接剂。本文还描述了制备固体支持硫化试剂的方法以及它们在寡核苷酸合成过程中的应用。
• New Method of Using N-Thio Compounds for Oligonucleotide Synthesis
  申请人：He Yigang

  公开号：US20130096291A1

  公开（公告）日：2013-04-18

  A method for synthesizing an oligonucleotide which comprises using a sulfurizing agent of general formula (I) for sulfurizing at least one phosphorus internucleotide linkage of a precursor of the oligonucleotide, wherein R is an aryl group or a heteroaryl group, which is bonded to the S-atom through an annular carbon atom; and R 1 and R 2 are independently organic residues, preferably a C1-C20 hydrocarbon residue. The method may further comprise purifying the oligonucleotide. Also included is a process for the synthesis of the sulfurizing agent.

  一种合成寡核苷酸的方法，包括使用一种通式（I）的硫化剂，对寡核苷酸前体的至少一个磷酸酯键进行硫化，其中R是芳基或杂环芳基，通过环状碳原子与S原子相连；R1和R2是独立的有机残基，优选是C1-C20烃基。该方法还可以包括纯化寡核苷酸。还包括一种合成硫化剂的过程。
• A NEW METHOD OF USING N-THIO COMPOUNDS FOR OLIGONUCLEOTIDE SYNTHESIS
  申请人：Girindus America, Inc.

  公开号：EP2588487B1

  公开（公告）日：2014-01-29
• US8710210B2
  申请人：——

  公开号：US8710210B2

  公开（公告）日：2014-04-29
• US8889843B2
  申请人：——

  公开号：US8889843B2

  公开（公告）日：2014-11-18