ethyl 2-pyrimidyl sulfoxide | 122080-52-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: ethyl 2-pyrimidyl sulfoxide
• 英文别名: ethyl 2-pyrimidinyl sulfoxide；2-Ethylsulfinylpyrimidine
• CAS: 122080-52-8
• 化学式: C₆H₈N₂OS
• 分子量: 156.208
• InChiKey: IWGBGLAAUUXRLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  62.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 2-pyrimidyl sulfoxide 、 苯基溴化镁 以 四氢呋喃 为溶剂， 反应 0.02h， 以50%的产率得到2-苯基嘧啶
  参考文献：
  名称：

  LIGAND COUPLING REACTIONS OF 2-PYRIDYL, 4-PYRIDYL AND 2-PYRIMIDYL SULFOXIDES WITH GRIGNARD REAGENTS

  摘要：

  The ligand coupling reaction was extended to 3- and 4-pyridyl sulfoxides as well as the 2-pyrimidyl moiety with Grignard reagents. It was found that both 4-pyridyl and 2-pyrimidyl sulfoxides nicely underwent the ligand coupling reactions, but 3-pyridyl sulfoxide underwent ligand exchange.

  DOI：

  10.1080/10426509608037965

文献信息

• Triazole compounds and methods of making and using the same
  申请人：Bhattacharjee Ashoke

  公开号：US20100016956A1

  公开（公告）日：2010-01-21

  The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. The compounds have the following structure: wherein T is the macrocyclic part.

  本发明提供了三唑大环化合物，作为治疗剂非常有用。更具体地说，这些化合物可用作抗感染、抗增殖、抗炎和促动力剂。化合物具有以下结构：其中T是大环部分。
• Triazole Compounds and Methods of Making and Using the Same
  申请人：Bhattacharjee Ashoke

  公开号：US20130065845A1

  公开（公告）日：2013-03-14

  The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

  本发明提供了三唑大环化合物，其作为治疗剂具有用途。更具体地说，这些化合物可作为抗感染、抗增殖、抗炎和促动力剂使用。
• Oae, Shigeru; Takeda, Takashi; Wakabayashi, Shoji, Heterocycles, 1989, vol. 28, # 1, p. 99 - 102
  作者：Oae, Shigeru、Takeda, Takashi、Wakabayashi, Shoji

  DOI：——

  日期：——
• Triazole Compounds And Methods Of Making And Using The Same
  申请人：Melinta Therapeutics, Inc.

  公开号：US20180094016A1

  公开（公告）日：2018-04-05

  The present invention provides triazole macrocyclic compounds useful as therapeutic agents. More particularly, these compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.
• US8278281B2
  申请人：——

  公开号：US8278281B2

  公开（公告）日：2012-10-02