1-Fluoro-6-(trifluoromethyl)pyridin-1-ium-2-sulfonate;hydron

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 1-Fluoro-6-(trifluoromethyl)pyridin-1-ium-2-sulfonate;hydron
• 英文别名: 1-fluoro-6-(trifluoromethyl)pyridin-1-ium-2-sulfonate;hydron
• 化学式: C6H4F4NO3S+
• 分子量: 246.16
• InChiKey: YRDNWLLASUEMBD-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66.6
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Vitamin D3 derivative and treating agent for inflammatory respiratory disease using same
  申请人：TEIJIN LIMITED

  公开号：US20020091109A1

  公开（公告）日：2002-07-11

  Compounds expressed by the following general formula (1), 1 [wherein, R 01 and R 02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1), (1-2), (1-3), (1-4) and (1-5)]. 2 The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.

  以下为一般式（1）表示的化合物，其中，R01和R02分别独立地表示氢原子或羟基的保护基团；Z为下列式子（1-1）、（1-2）、（1-3）、（1-4）和（1-5）中的一种。这些化合物可以用作治疗炎症性呼吸道疾病、恶性肿瘤、类风湿性关节炎、骨质疏松症、糖尿病、高血压、脱发、痤疮、银屑病、皮炎、高钙血症、甲状旁腺功能减退症和软骨代谢紊乱的治疗剂的活性成分。
• Amine derivatives
  申请人：——

  公开号：US20040259875A1

  公开（公告）日：2004-12-23

  An amine derivative, its tautomeric or stereoisomeric form, or a salt thereof which has vanilloid receptor 1 (VR1) antagonistic activity, is disclosed. The amine derivative has an excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, incontinence and/or inflammatory disorders.

  本发明揭示了一种具有vanilloid receptor 1（VR1）拮抗活性的胺衍生物、其互变异构体或立体异构体形式或其盐。该胺衍生物具有优异的VR1拮抗活性，适用于预防和治疗与VR1活性相关的疾病，特别是用于治疗尿失禁、过度活动膀胱、慢性疼痛、神经痛、术后疼痛、类风湿性关节炎疼痛、神经痛、神经病、疼痛、神经损伤、缺血、神经退行性疾病、中风、失禁和/或炎症性疾病。
• ELECTROLYTIC SOLUTION AND DEVICE FOR GENERATING ELECTRIC ENERGY THEREWITH
  申请人：Daikin Industries, Ltd.

  公开号：EP0948073A1

  公开（公告）日：1999-10-06

  An electrolyte containing at least one of dihalodicarbonyl compounds, in which hydrogen atoms of a methylene group between the two carbonyl groups are substituted with halogen atoms, and an electric energy generator comprising the electrolyte, an active material for positive electrode and an active material for negative electrode. The electrolyte has high polarity, high resistance to oxidation and flame retardance, and thus possesses excellent characteristics as the electrolyte for electric energy generators.

  一种含有至少一种二卤代羰基化合物（其中两个羰基之间的亚甲基的氢原子被卤素原子取代）的电解液，以及一种由该电解液、正极活性材料和负极活性材料组成的电能发生器。该电解液具有高极性、高抗氧化性和阻燃性，因此具有作为电能发生器电解液的优良特性。
• VITAMIN D 3? DERIVATIVES AND REMEDIES FOR INFLAMMATORY RESPIRATORY DISEASES CONTAINING THE SAME
  申请人：TEIJIN LIMITED

  公开号：EP1123921A1

  公开（公告）日：2001-08-16

  Compounds expressed by the following general formula (1), [wherein, R01 and R02 are each independently a hydrogen atom or a protecting group for a hydroxyl group; Z is one out of the following formulae (1-1), (1-2), (1-3), (1-4) and (1-5)]. The compounds can be used as active ingredients of treating agents for inflammatory respiratory diseases, malignant tumors, rheumatoid arthritis, osteoporosis, diabetes mellitus, hypertension, alopecia, acne, psoriasis, dermatitis, hypercalcemia, hypoparathyroidism and metabolic disorder of cartilage.

  由以下通式(1)表示的化合物、 [其中，R01 和 R02 各自独立地为氢原子或羟基的保护基团；Z 为下式 (1-1)、(1-2)、(1-3)、(1-4) 和 (1-5) 中的一种]。 这些化合物可用作治疗炎症性呼吸道疾病、恶性肿瘤、类风湿性关节炎、骨质疏松症、糖尿病、高血压、脱发、痤疮、牛皮癣、皮炎、高钙血症、甲状旁腺功能减退症和软骨代谢紊乱的药物的活性成分。
• CONDENSATION COMPOUND BETWEEN FLUORINATED CYCLOPENTANE RING AND AROMATIC RING, AND PROCESS FOR PRODUCING THE SAME
  申请人：OSAKA UNIVERSITY

  公开号：EP1857452A1

  公开（公告）日：2007-11-21

  A condensation compound of a fluorinated cyclopentane ring and an aromatic ring, which is useful, for example, for electronic materials, and a process for producing the same are provided. For instance, according to Scheme 1 below, a compound (68) containing a condensed structure formed of a hexafluorocyclopentane ring and an aromatic ring is synthesized. The aromatic ring is not limited to a thiophene ring but can be any ring and any substituent can be used. Thus a compound containing a condensed ring structure formed of a hexafluorocyclopentane ring and an aromatic ring, particularly, for instance, a thiophene ring, which was impossible to produce conventionally, can be produced easily with high yield. The compound of the present invention is particularly suitable to be applied to, for example, electronic materials or semiconductors. When it is polymerized and thereby the π-electronic conjugation is extended, it also is expected to be applied to, for example, n-type organic semiconductors and molecular wires that are indispensable for developing molecular electronics elements.

  本发明提供了一种可用于电子材料等的氟化环戊烷环和芳香环的缩合化合物及其生产工艺。例如，根据下面的方案 1，合成了一种含有六氟环戊烷环和芳香环缩合结构的化合物 (68)。芳香环不限于噻吩环，可以是任何环，也可以使用任何取代基。因此，包含由六氟环戊烷环和芳香环（尤其是噻吩环）形成的缩合环结构的化合物可以很容易地以高产率生产出来。本发明的化合物尤其适用于电子材料或半导体等领域。当它被聚合从而扩展了 π-电子共轭时，它也有望应用于例如开发分子电子元件所不可或缺的 n 型有机半导 体和分子线。