(2R,3R)-2,3-dibenzoyloxy-3-(diethylcarbamoyl)propanoic acid | 115061-39-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,3R)-2,3-dibenzoyloxy-3-(diethylcarbamoyl)propanoic acid
• 英文别名: N,N-diethyl-O²,O³-dibenzoyl-L_g-tartramic acid；N,N-Diaethyl-O²,O³-dibenzoyl-L_g-tartramidsaeure；(2R,3R)-2,3-dibenzoyloxy-4-(diethylamino)-4-oxobutanoic acid
• CAS: 115061-39-7
• 化学式: C₂₂H₂₃NO₇
• 分子量: 413.427
• InChiKey: HERDIXDWRYMFKG-QZTJIDSGSA-N

物化性质

• 熔点：
  135-136 °C
• 沸点：
  623.3±55.0 °C(predicted)
• 密度：
  1.272±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  30
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 (2R,3R)-2,3-dibenzoyloxy-3-(diethylcarbamoyl)propanoic acid 在 乙醚 作用下， 生成 N,N-diethyl-O²,O³-dibenzoyl-L_g-tartramic acid methyl ester
  参考文献：
  名称：

  Prevalence and etiology of vertigo in adult rural population

  摘要：

  A survey on 10.000 adults between the age of 20 and 79 years out of a total population of 66.186 persons in rural settlements under the inrisduction of Union Territory of Chandigarh between June 1993 to June 1995 was conducted to find out the prevalence and various causes of vertigo. In general community, in rural population, we found that more people suffer from non-otologic vertigo rather than otologic vertigo. We found overall prevalence of vertigo in rural adult community to be 0.71%. Vertigo secondary to cardiovascular disease was most common and prevalent in 0.32% of population. Neurologic disease accounted for vertigo in 0.14%, metabolic disease in 0.09% and otologic disease 0.08%. Miscellaneous disorders were present in remaining 0.08% of population studied. To the best of our knowledge this study represents the first population based survey of prevalence of various causes of vertigo in general community in adult rural population.

  DOI：

  10.1007/bf02910976
• 作为产物：
  描述：

  二乙胺 、 (+)-二苄氧基-L-酒石酸酐 以 苯 为溶剂， 生成 (2R,3R)-2,3-dibenzoyloxy-3-(diethylcarbamoyl)propanoic acid
  参考文献：
  名称：

  Bell, Kevin H., Australian Journal of Chemistry, 1987, vol. 40, # 10, p. 1723 - 1735

  摘要：

  DOI：

文献信息

• Process for the separation of the cis trans diasteroisomers of tramadol
  申请人：——

  公开号：US20030092773A1

  公开（公告）日：2003-05-15

  A process for separating a mixture of trans (RR, SS) and cis (RS, SR) tramadol comprises a classical salt resolution using a chiral resolving agent selected from tartaric acid and derivatives thereof, and mandelic acid, provided that the resolving agent is not substantially single enantiomer di-O,O-toluoyltartaric acid.

  一种用于分离由trans (RR, SS)和cis (RS, SR)组成的曲马多混合物的过程，包括使用从酒石酸及其衍生物和苯乙酸中选择的手性分离剂进行经典盐析分离，前提是分离剂不是实质上的单对映体二-O,O-苯甲酰酒石酸。
• Conformational disparity of (R,R)-tartaric acid esters and amides
  作者：Jacek Gawronski、Krystyna Gawronska、Urszula Rychlewska

  DOI：10.1016/s0040-4039(01)93857-2

  日期：1989.1

  Exciton chirality method is used to determine anti and gauche conformations, respectively, of ester and dialkylamide derivatives of (R,R) - tartaric acid. Gauche conformation of (R,R)-N,N,N′-tetramethyltartamide and its O,O-dibenzoyl derivative is found in the solid state by X-ray analysis.

  激子手性法分别用于确定（R，R）-酒石酸的酯和二烷基酰胺衍生物的反构象和gauche构象。通过X射线分析发现（R，R）-N，N，N′-四甲基酒石酰胺及其O，O-二苯甲酰基衍生物的Gauche构象。
• BELL, KEVIN H., AUSTRAL. J. CHEM., 40,(1987) N 10, 1723-1735
  作者：BELL, KEVIN H.

  DOI：——

  日期：——
• Bell, Kevin H., Australian Journal of Chemistry, 1987, vol. 40, # 10, p. 1723 - 1735
  作者：Bell, Kevin H.

  DOI：——

  日期：——
• Prevalence and etiology of vertigo in adult rural population
  作者：Raman Abrol、Vikas I. Nehru、Y. Venkatramana

  DOI：10.1007/bf02910976

  日期：2001.1

  A survey on 10.000 adults between the age of 20 and 79 years out of a total population of 66.186 persons in rural settlements under the inrisduction of Union Territory of Chandigarh between June 1993 to June 1995 was conducted to find out the prevalence and various causes of vertigo. In general community, in rural population, we found that more people suffer from non-otologic vertigo rather than otologic vertigo. We found overall prevalence of vertigo in rural adult community to be 0.71%. Vertigo secondary to cardiovascular disease was most common and prevalent in 0.32% of population. Neurologic disease accounted for vertigo in 0.14%, metabolic disease in 0.09% and otologic disease 0.08%. Miscellaneous disorders were present in remaining 0.08% of population studied. To the best of our knowledge this study represents the first population based survey of prevalence of various causes of vertigo in general community in adult rural population.