N-t-butyl-N'-benzyloxycarbonyl-N-benzoylhydrazine | 284044-47-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-t-butyl-N'-benzyloxycarbonyl-N-benzoylhydrazine
• 英文别名: Benzyl 2-benzoyl-2-tert-butylhydrazinecarboxylate；benzyl N-[benzoyl(tert-butyl)amino]carbamate
• CAS: 284044-47-9
• 化学式: C₁₉H₂₂N₂O₃
• 分子量: 326.395
• InChiKey: YPQUTWQUWGUELA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-t-butyl-N'-benzyloxycarbonyl-N-benzoylhydrazine 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 以96.4%的产率得到N-tert-butyl-N-benzoylhydrazine
  参考文献：
  名称：

  1-OXO-4-CHLOROCARBONYL-1-PHOSPHA-2,6,7-TRIOXABICYCLO[2.2.2]辛烷与Nt-丁基-N-苯甲肼的缩合反应

  摘要：

  摘要 1-Oxo-4-chlorocarbony1-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane (5) 从三氯化磷中得到。苯甲醇与三光气反应首次以良好的收率合成了氯甲酸苄酯。Nr-丁基-N-苯甲酰肼(II) 是以一种新的、简便的方法制备的，产率很高。在碳酸钠存在下，5和II反应顺利进行，以良好的收率得到所需化合物13，而在三乙胺存在下，观察到丁基被消除，得到化合物12。

  DOI：

  10.1080/10426500008042105
• 作为产物：
  描述：

  氯甲酸苄酯 在 sodium hydroxide 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 4.0h， 生成 N-t-butyl-N'-benzyloxycarbonyl-N-benzoylhydrazine
  参考文献：
  名称：

  1-OXO-4-CHLOROCARBONYL-1-PHOSPHA-2,6,7-TRIOXABICYCLO[2.2.2]辛烷与Nt-丁基-N-苯甲肼的缩合反应

  摘要：

  摘要 1-Oxo-4-chlorocarbony1-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane (5) 从三氯化磷中得到。苯甲醇与三光气反应首次以良好的收率合成了氯甲酸苄酯。Nr-丁基-N-苯甲酰肼(II) 是以一种新的、简便的方法制备的，产率很高。在碳酸钠存在下，5和II反应顺利进行，以良好的收率得到所需化合物13，而在三乙胺存在下，观察到丁基被消除，得到化合物12。

  DOI：

  10.1080/10426500008042105

文献信息

• CONDENSATION REACTION OF 1-OXO-4-CHLOROCARBONYL-1-PHOSPHA-2,6,7-TRIOXABICYCLO[2.2.2]OCTANE WITH N-<i>t</i>-BUTYL-<i>N</i>-BENZOYLHYDRAZINE
  作者：Qingmin Wang、Runqiu Huang

  DOI：10.1080/10426500008042105

  日期：2000.6.1

  7-trioxabicyclo[2.2.2]octane (5) was obtained from phosphorus oxychloride. Benzyl chloroformate was synthesized by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-r-Butyl-N-benzoylhydrazine(II) was prepared in a new and convenivent procedure with good yield. The reaction of 5 and II proceeded smoothly in the presence of sodium carbonate and afforded the desired compound

  摘要 1-Oxo-4-chlorocarbony1-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane (5) 从三氯化磷中得到。苯甲醇与三光气反应首次以良好的收率合成了氯甲酸苄酯。Nr-丁基-N-苯甲酰肼(II) 是以一种新的、简便的方法制备的，产率很高。在碳酸钠存在下，5和II反应顺利进行，以良好的收率得到所需化合物13，而在三乙胺存在下，观察到丁基被消除，得到化合物12。
• Synthesis and biological activity of novel N ′- tert -butyl- N ′-substituted benzoyl- N -(substituted phenyl)aminocarbonylhydrazines and their derivatives
  作者：Qingmin Wang、Runqiu Huang

  DOI：10.1016/s0040-4039(01)01932-3

  日期：2001.12

  Benzyl chloroformate was synthesised by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-tert-Butyl-N-substituted benzoylhydrazines were prepared in a new and convenient procedure with good yields. A series of novel N'-tert-butyl-N'-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives were synthesised and evaluated for molting hormone mimicking activity. The results of bioassays showed that the title compounds exhibit good larvicidal activities and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We have found that the title compounds possess potential anticancer activities. (C) 2001 Elsevier Science Ltd. All rights reserved.
• A Convenient Synthesis of Novel<i>N</i>′-<i>tert</i>-Butyl-<i>N</i>′-Substituted Benzoyl-<i>N</i>-(Substituted Phenyl)aminocarbonylhydrazines and Their Derivatives
  作者：Qingmin Wang、Runqiu Huang

  DOI：10.1081/scc-120027261

  日期：2004.1

  N-tert-butyl-N-substituted benzoylhydrazines were prepared in two convenient procedures with good yields, subsequent reaction with substituted phenylisocyanates in 1,2-dichloroethane provided a series of novel N'-tert-butyl-N'-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines. Further treatment with oxalyl chloride gave their derivatives in good yields. The title compounds exhibit moderate larvicidal activities and anticancer activities.