2-ethoxy-N-(6-oxoheptyl)acetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-ethoxy-N-(6-oxoheptyl)acetamide
• 化学式: C₁₁H₂₁NO₃
• 分子量: 215.29
• InChiKey: KGRNZLUGCQFXMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Polypeptide protracting tags
  申请人：Dorwald Florencio Zaragoza

  公开号：US20090111730A1

  公开（公告）日：2009-04-30

  Method for increasing (protracting) half-life of LGP analogs in plasma and novel derivatives of such peptides based on covalently linking them to a tetrazole moiety which acts as a carboxylic acid bioisostere.

  一种增加LGP类似物在血浆中半衰期的方法以及基于共价连接到四唑基团的新型衍生物，该四唑基团作为羧酸生物异构体。
• Double-Acylated GLP-1 Derivatives
  申请人：Madsen Alice Ravn

  公开号：US20130288960A1

  公开（公告）日：2013-10-31

  The invention relates to a derivative of a GLP-1 analogue, which analogue comprises a first K residue at a position corresponding to position 18 of GLP-1 (7-37) (SEQ ID NO: 1), a second K residue at another position, and a maximum of twelve amino acid changes as compared to GLP-1 (7-37); which derivative comprises two protracting moieties attached to said first and second K residue, respectively, via a linker, wherein the protracting moiety is selected from Chem. 1, Chem. 2, and Chem. 3: Chem.: HOOC—(CH 2 ) x —CO—* Chem. 2: HOOC—C 6 H 4 -0-(CH 2 ) y —CO—* Chem. 3: R 2 —C 6 H 4 —(CH 2 ) z —CO—*, in which x is an integer in the range of 6-18, y is an integer in the range of 3-17, z is an integer in the range of 1-5, and R 2 is a group having a molar mass not higher than 150 Da; and the linker comprises Chem. 4: *—NH—(CH 2 ) 2 -(0-(CH 2 ) 2 ) k -0-(CH 2 ) n —CO—*. wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel peptides and side chain intermediates. The derivatives are suitable for oral administration.
• US9708383B2
  申请人：——

  公开号：US9708383B2

  公开（公告）日：2017-07-18