2-(3-Chloro-phenylamino)-propionic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(3-Chloro-phenylamino)-propionic acid
• 英文别名: 2-(3-chloroanilino)propanoic acid
• 化学式: C₉H₁₀ClNO₂
• 分子量: 199.63
• InChiKey: WIXUZVQMOUIMNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Use of antagonists of the bradykinin B2 receptor for the treatment of osteoarthrosis
  申请人：Aventis Pharma Deutschland GmbH

  公开号：US20040248809A1

  公开（公告）日：2004-12-09

  Peptides having bradykinin-antagonistic action are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases in whose course an increased activity of matrix metalloproteinases is involved. These include diseases such as degenerative joint diseases, for example osteoarthrosis, spondylosis and chondroporosis after joint trauma or relatively long immobilization of a joint after meniscus or patella injuries or torn ligaments. The invention therefore relates to the use of a compound of the formula I, A-B-X-E-F-K-(D)-TIC-G-M-F′-I  (I) for the production of pharmaceuticals for the treatment of degenerative joint diseases, wherein A, B, X, E, F, K, (D)-TIC, G, M, F′ and I are as defined herein.
• Use of Antagonists of the Bradykinin B2 Receptor for the Treatment of Osteoarthrosis
  申请人：Michaelis Martin

  公开号：US20090023661A1

  公开（公告）日：2009-01-22

  Peptides having bradykinin-antagonistic action are suitable for the production of pharmaceuticals for the prophylaxis and therapy of diseases in whose course an increased activity of matrix metalloproteinases is involved. These include diseases such as degenerative joint diseases, for example osteoarthrosis, spondylosis and chondroporosis after joint trauma or relatively long immobilization of a joint after meniscus or patella injuries or torn ligaments. The invention therefore relates to the use of a compound of the formula I, A-B-X-E-F-K-(D)-TIC-G-M-F′-I  (I) for the production of pharmaceuticals for the treatment of degenerative joint diseases, wherein A, B, X, E, F, K, (D)-TIC, G, M, F′ and I are as defined herein.
• ANTIFOULING MATERIALS
  申请人：YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD

  公开号：US20160376449A1

  公开（公告）日：2016-12-29

  The invention provided herein presents a novel family of antifouling agents based on hydroxylated and fluorinated compounds.
• US4412076A
  申请人：——

  公开号：US4412076A

  公开（公告）日：1983-10-25
• US4421920A
  申请人：——

  公开号：US4421920A

  公开（公告）日：1983-12-20