6-(羟基甲基)-3-吡啶醇1-氧化物 | 73737-02-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 6-(羟基甲基)-3-吡啶醇1-氧化物
• 英文名称: 5-hydroxy-2-pyridinemethanol 1-oxide
• 英文别名: 6-(Hydroxymethyl)-1-oxo-1lambda~5~-pyridin-3-ol；6-(hydroxymethyl)-1-oxidopyridin-1-ium-3-ol
• CAS: 73737-02-7
• 化学式: C₆H₇NO₃
• 分子量: 141.126
• InChiKey: KFLBUEICGZUSQT-UHFFFAOYSA-N

物化性质

• 熔点：
  183-184 °C
• 沸点：
  510.7±35.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  65.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(羟基甲基)-3-吡啶醇1-氧化物 在 manganese(IV) oxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以53%的产率得到5-Hydroxy-1-oxy-pyridine-2-carbaldehyde
  参考文献：
  名称：

  Synthesis and antineoplastic activity of phenyl-substituted phenylsulfonylhydrazones of 1-pyridinecarboxaldehyde 1-oxide

  摘要：

  A variety of derivatives of 2-pyridinecarboxaldehyde 1-oxide benzenesulfonylhydrazone, containing substituents on the benzene or pyridine rings as well as on the nitrogen atom which is bonded directly to the sulfonyl group, have been synthesized. The antineoplastic activity of these compounds has been assessed in mice bearing either leukemia L1210 or P388. The most potent agents in this series were 2,4-dimethoxy,3,4-dimethoxy-, and 2,4,6-trimethylbenzenesulfonylhydrazone of 2-pyridinecarboxyaldehyde 1-oxide, all causing disappearance of tumors in 20-80% of leukemia-bearing mice.

  DOI：

  10.1021/jm00180a010
• 作为产物：
  描述：

  5-羟基-2-吡啶甲醇 在 间氯过氧苯甲酸 作用下， 以 甲醇 、 氯仿 为溶剂， 以88%的产率得到6-(羟基甲基)-3-吡啶醇1-氧化物
  参考文献：
  名称：

  Synthesis and antineoplastic activity of phenyl-substituted phenylsulfonylhydrazones of 1-pyridinecarboxaldehyde 1-oxide

  摘要：

  A variety of derivatives of 2-pyridinecarboxaldehyde 1-oxide benzenesulfonylhydrazone, containing substituents on the benzene or pyridine rings as well as on the nitrogen atom which is bonded directly to the sulfonyl group, have been synthesized. The antineoplastic activity of these compounds has been assessed in mice bearing either leukemia L1210 or P388. The most potent agents in this series were 2,4-dimethoxy,3,4-dimethoxy-, and 2,4,6-trimethylbenzenesulfonylhydrazone of 2-pyridinecarboxyaldehyde 1-oxide, all causing disappearance of tumors in 20-80% of leukemia-bearing mice.

  DOI：

  10.1021/jm00180a010

文献信息

• Electronically Modified Polymer-supported Cinchona Phase-transfer Catalysts for Asymmetric Synthesis of α-Alkyl-α-amino Acid Derivatives
  作者：Qinghua Shi、Yeon-Ju Lee、Hongrui Song、Maosheng Cheng、Sang-sup Jew、Hyeung-geun Park、Byeong-Seon Jeong

  DOI：10.1246/cl.2008.436

  日期：2008.4.5

  Merrifield resin-supported hydrocinchonidinium salts containing particular functional groups that can participate in hydrogen bonding were prepared and evaluated as chiral phase-transfer catalysts using the asymmetric benzylation of glycine imine ester. These electronically modified Merrifield resin-supported phase-transfer catalysts generally provided better enantioselectivities compared to the unmodified ones.

  利用甘氨酸亚胺酯的不对称苄化反应，制备并评估了作为手性相转移催化剂的含有可参与氢键作用的特定官能团的 Merrifield 树脂支撑的氢化琥珀酰亚胺盐。与未修饰的催化剂相比，这些电子修饰的 Merrifield 树脂支撑相转移催化剂通常具有更好的对映选择性。
• LOH W.; COSBY L. A.; SARTORELLI A. C., J. MED. CHEM., 1980, 23, NO 6, 631-634
  作者：LOH W.、 COSBY L. A.、 SARTORELLI A. C.

  DOI：——

  日期：——