1,3-Di(octadec-9-enoyloxy)propyl-trimethylazanium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1,3-Di(octadec-9-enoyloxy)propyl-trimethylazanium
• 英文别名: 1,3-di(octadec-9-enoyloxy)propyl-trimethylazanium
• 化学式: C42H80NO4+
• 分子量: 663.1
• InChiKey: UZWMMDLLJGXMOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.5
• 重原子数：
  47
• 可旋转键数：
  37
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Synthesis and use of reagents for improved DNA lipofection and/or slow release prodrug and drug therapies
  申请人：Diamond L. Scott

  公开号：US20050069577A1

  公开（公告）日：2005-03-31

  The invention relates to compositions and methods for a one-step synthetic technique for making cationic steroid or cationic drug molecules for use as delivery vehicles. The invention further relates to methods for using cationic steroid molecules in lipofection or transfection, delivery of drugs, and for treatment of inflammation and other diseases and disorders. The invention also relates to cationic steroid prodrugs and cationic prodrugs and to methods of modifying drugs.

  本发明涉及一种用于制备阳离子类固醇或阳离子类药物分子的一步合成技术的组合物和方法，用作传递载体。该发明还涉及使用阳离子类固醇分子进行脂质体转染或转染、药物传递以及治疗炎症和其他疾病和障碍的方法。该发明还涉及阳离子类固醇前药和阳离子前药以及修改药物的方法。
• Synthesis and Use of Cationic Steroids for Anti-Inflammatory Drug Therapy
  申请人：Diamond Scott L.

  公开号：US20090124591A1

  公开（公告）日：2009-05-14

  The invention relates to compositions and methods for a one-step synthetic technique for making cationic steroid pharmaceutical compositions for use in treating inflammation and other diseases and disorders.

  本发明涉及一种用于制备阳离子类固醇药物组合物的一步合成技术及其用于治疗炎症和其他疾病和障碍的方法。
• Antimicrobial Cationic Steroids and Methods of Use
  申请人：Fein David E.

  公开号：US20130137668A1

  公开（公告）日：2013-05-30

  The invention relates generally to antimicrobial cationic steroid pharmaceutical compositions, methods of making antimicrobial cationic steroid pharmaceutical compositions, and methods of using antimicrobial cationic steroid pharmaceutical compositions.

  该发明涉及抗微生物阳离子类固醇药物组成物、制备抗微生物阳离子类固醇药物组成物的方法，以及使用抗微生物阳离子类固醇药物组成物的方法。
• SYNTHESIS AND USE OF REAGENTS FOR IMPROVED DNA LIPOFECTION AND/OR SLOW RELEASE PRODRUG AND DRUG THERAPIES
  申请人：The Trustees of The University of Pennsylvania

  公开号：EP1424998A1

  公开（公告）日：2004-06-09
• EP1424998A4
  申请人：——

  公开号：EP1424998A4

  公开（公告）日：2005-11-23