1,4-Diaminocyclohexane-1-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,4-Diaminocyclohexane-1-carboxamide
• 英文别名: 1,4-diaminocyclohexane-1-carboxamide
• 化学式: C₇H₁₅N₃O
• 分子量: 157.21
• InChiKey: OOWWJNFEFMGACZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  95.1
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] METHODS OF LOCAL INDUCTION OF T REGULATORY CELLS<br/>[FR] PROCÉDÉS D'INDUCTION LOCALE DE CELLULES T RÉGULATRICES
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2016176501A1

  公开（公告）日：2016-11-03

  The instant disclosure provides methods of locally increasing the number T regulatory (Treg) cells, in particular Foxp3-expressing Treg cells, in the damaged epithelium of a subject by administering to the subject an agonist of the hedgehog signaling pathway. Also provided are methods of preventing a condition associated with damaged epithelium by prophylactically inducing Foxp3 -expressing Treg cells by administering a Hedgehog pathway agonist in a subject at risk of developing such a condition. Also provided are pharmaceutical compositions and kits comprising Hedgehog agonists formulated for use in the described methods.