Ethyl 3-azido-3-hydroxybutanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ethyl 3-azido-3-hydroxybutanoate
• 英文别名: ethyl 3-azido-3-hydroxybutanoate
• 化学式: C6H11N3O3
• 分子量: 173.17
• InChiKey: XLMHWPKLLRDGNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  60.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Method of Making Optically Active Ester Derivatives and Their Acids From Racemic Esters
  申请人：Hwang Ook Soon

  公开号：US20080038802A1

  公开（公告）日：2008-02-14

  The present invention relates to process for the preparing of optically active ester derivatives and their acid derivatives which are used intensively as important chiral intermediates from racemic β-hydroxybutyl ester derivatives. In more detail, this invention relates to the process for preparing optically active β-hydroxybutyl ester derivatives and their acid derivatives by stereospecific hydrolysis of racemic β-hydroxybutyl ester derivatives using Upases or lipase-producing microorganisms in the aqueous phase or organic phase including aqueous solvent. The method of making optically active ester derivatives and their acid derivatives by hydrolysis of β-hydroxybutyl ester derivatives represented by the general formula 1 in scheme 1 is easier and more economical comparing to the conventional methods and the products have high optical purity. Also separation of ester derivatives from acid derivatives is easy after reaction. Thus this method is a useful process on the industrial scale.

  本发明涉及一种从外消旋β-羟基丁酸酯衍生物中制备光学活性酯衍生物及其酸衍生物的方法，这些酯衍生物和酸衍生物被广泛用作重要的手性中间体。更具体地说，本发明涉及一种通过使用水相或有机相包括水溶剂中的Upases或产生脂肪酶的微生物对外消旋β-羟基丁酸酯衍生物进行立体特异性水解制备光学活性β-羟基丁酸酯衍生物及其酸衍生物的方法。与传统方法相比，通过β-羟基丁酸酯衍生物的水解制备光学活性酯衍生物及其酸衍生物的方法更加容易和经济，而且产品的光学纯度高。此外，反应后酯衍生物和酸衍生物的分离也很容易。因此，该方法是一个在工业规模上有用的过程。
• THE METHOD OF MAKING OPTICALLY ACTIVE ESTER DERIVATIVES AND THEIR ACIDS FROM RACEMIC ESTERS
  申请人：Enzytech, Ltd.

  公开号：EP1740714A1

  公开（公告）日：2007-01-10
• US7485452B2
  申请人：——

  公开号：US7485452B2

  公开（公告）日：2009-02-03
• [EN] THE METHOD OF MAKING OPTICALLY ACTIVE ESTER DERIVATIVES AND THEIR ACIDS FROM RACEMIC ESTERS<br/>[FR] FABRICATION DE DERIVES D'ESTERS OPTIQUEMENT ACTIFS ET DE LEURS ACIDES PROVENANT D'ESTERS RACEMIQUES
  申请人：ENZYTECH LTD

  公开号：WO2005111227A1

  公开（公告）日：2005-11-24

  The present invention relates to process for the preparing of optically active ester derivatives and their acid derivatives which are used intensively as important chiral intermediates from racemic β-hydroxybutyl ester derivatives. In more detail, this invention relates to the process for preparing optically active β-hydroxybutyl ester derivatives and their acid derivatives by stere-ospecific hydrolysis of racemic β-hydroxybutyl ester derivatives using Upases or lipase-producing microorganisms in the aqeous phase or organic phase including aqeous solvent. The method of making optically active ester derivatives and their acid derivatives by hydrolysis of β-hydroxybutyl ester derivatives represented by the general formula 1 in scheme 1 is easier and more economical comparing to the conventional methods and the products have high optical purity. Also separation of ester derivatives from acid derivatives is easy after reaction. Thus this method is a useful process on the industrial scale.