O-(4-Methoxybenzyl)hydroxylaminehydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: O-(4-Methoxybenzyl)hydroxylaminehydrochloride
• 英文别名: (4-methoxyphenyl)methoxyazanium;chloride
• 化学式: C8H12ClNO2
• 分子量: 189.64
• InChiKey: UMBKWIIPZYVJJP-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.63
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.1
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade
  申请人：Pharmacia Corporation

  公开号：US20040082585A1

  公开（公告）日：2004-04-29

  The present invention relates to prodrug compounds, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The prodrug compounds of the present invention selectively inhibit certain proteases of the coagulation cascade.

  本发明涉及一种用于预防和治疗哺乳动物血栓性疾病的前药化合物、组合物和方法。本发明的前药化合物选择性地抑制凝血级联反应中的某些蛋白酶。
• PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE
  申请人：Pharmacia Corporation

  公开号：EP1482940A2

  公开（公告）日：2004-12-08
• [EN] PRODRUGS OF SUBSTITUTED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE<br/>[FR] PROMEDICAMENTS DE COMPOSES POLYCYCLIQUES SUBSTITUES UTILES POUR L'INHIBITION SELECTIVE DE LA CASCADE DE LA COAGULATION
  申请人：PHARMACIA CORP

  公开号：WO2003028729A2

  公开（公告）日：2003-04-10

  The present invention relates to prodrug compounds, comprising a 5- or 6- membered heterocyclic or aromatic ring substituted with a derivatized amidine, as well as compositions and methods useful for preventing and treating thrombotic conditions in mammals. The prodrug compounds of the present invention selectively inhibit certain proteases of the coagulation cascade.