N-Allyl-2-azido-5-chloro-N-methyl-benzamide | 1026423-55-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Allyl-2-azido-5-chloro-N-methyl-benzamide
• 英文别名: 2-azido-5-chloro-N-methyl-N-prop-2-enylbenzamide
• CAS: 1026423-55-1
• 化学式: C₁₁H₁₁ClN₄O
• 分子量: 250.688
• InChiKey: JCHNJCLMCNQKEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  34.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-Allyl-2-azido-5-chloro-N-methyl-benzamide 以 甲苯 为溶剂， 反应 1.0h， 生成 7-Chloro-2,4-dimethyl-3,4-dihydro-benzo[e][1,4]diazepin-5-one
  参考文献：
  名称：

  Broggini, Gianluigi; Zecchi, Gaetano; Molteni, Giorgio, Gazzetta Chimica Italiana, 1997, vol. 127, # 12, p. 809 - 810

  摘要：

  DOI：
• 作为产物：
  描述：

  5-氯靛红酸酐 在 盐酸 、 sodium azide 、 sodium nitrite 作用下， 以 乙醚 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.25h， 生成 N-Allyl-2-azido-5-chloro-N-methyl-benzamide
  参考文献：
  名称：

  Microwave enhanced solution synthesis of 1,4-benzodiazepin-5-ones

  摘要：

  Some 2-methyl-1,4-benzodiazepin-5-ones have been synthesized by the application of microwave irradiation. Conventional heating and microwave irradiation of the reactions were compared. Synthesis by microwave irradiation gave the desired compounds in better yields than those obtained by conventional heating. The overall times for the syntheses were considerably reduced. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00155-1

文献信息

• Broggini, Gianluigi; Zecchi, Gaetano; Molteni, Giorgio, Gazzetta Chimica Italiana, 1997, vol. 127, # 12, p. 809 - 810
  作者：Broggini, Gianluigi、Zecchi, Gaetano、Molteni, Giorgio

  DOI：——

  日期：——
• Microwave enhanced solution synthesis of 1,4-benzodiazepin-5-ones
  作者：Vincenzo Santagada、Elisa Perissutti、Ferdinando Fiorino、Beniamino Vivenzio、Giuseppe Caliendo

  DOI：10.1016/s0040-4039(01)00155-1

  日期：2001.3

  Some 2-methyl-1,4-benzodiazepin-5-ones have been synthesized by the application of microwave irradiation. Conventional heating and microwave irradiation of the reactions were compared. Synthesis by microwave irradiation gave the desired compounds in better yields than those obtained by conventional heating. The overall times for the syntheses were considerably reduced. (C) 2001 Elsevier Science Ltd. All rights reserved.