6-[(3-羟基苯基)(甲基)氨基]己酸 | 887353-92-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 6-[(3-羟基苯基)(甲基)氨基]己酸
• 中文别名: 硅酸,盐铝锌；(4S)-4,6-BIS-[(叔丁基二甲基硅烷基)氧] -3,3-二甲基己基-2-一
• 英文名称: N-(5-Carboxypentyl)-3-hydroxy-N-methylaniline
• 英文别名: 6-(3-hydroxy-N-methylanilino)hexanoic acid
• CAS: 887353-92-6
• 化学式: C₁₃H₁₉NO₃
• 分子量: 237.299
• InChiKey: DMBQUFNFVJPLMV-UHFFFAOYSA-N

物化性质

• 沸点：
  447.0±25.0 °C(Predicted)
• 密度：
  1.168±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  60.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Dye compounds
  申请人：SFC CO., LTD.

  公开号：US10473666B2

  公开（公告）日：2019-11-12

  The present invention relates to dye compounds represented by Formulae I and II, which are described in the specification. The dye compounds of the present invention have markedly improved quantum yields and emit strong fluorescence compared to existing cyanine dyes. Due to these advantages, the dye compounds of the present invention can find applications in various fields, for example, as probes for various biological systems where optical imaging is required. Particularly, the dye compounds of the present invention can be used as mitotrackers capable of labeling and tracking mitochondria. Therefore, the dye compounds of the present invention can be used to quantitatively image mitochondria in live tissues and cells. Furthermore, the dye compounds of the present invention can be applied as pH probes for measuring the pH of live cells.

  本发明涉及由式I和II表示的染料化合物，这些化合物在说明书中有描述。与现有的青菁染料相比，本发明的染料化合物具有明显改善的量子产率，并且发射强烈的荧光。由于这些优点，本发明的染料化合物可以在各个领域找到应用，例如，作为各种生物系统的探针，其中需要光学成像。特别地，本发明的染料化合物可以用作能够标记和追踪线粒体的有丝分裂追踪剂。因此，本发明的染料化合物可以用于定量成像活体组织和细胞中的线粒体。此外，本发明的染料化合物可以作为用于测量活细胞pH值的pH探针。
• Fluorogenic pH-sensitive dyes, film and kit comprising the same
  申请人：SFC CO., LTD.

  公开号：US11041812B2

  公开（公告）日：2021-06-22

  The present disclosure relates to a fluorogenic pH-sensitive dye and a film for detecting pH using the fluorogenic pH-sensitive dye on a polymer film. The fluorogenic pH-sensitive dye includes an aryl compound having a sulfonyl group (—SO2) and an agarose compound covalently bonded to the sulfonyl group (—SO2) of the aryl compound.

  本公开涉及一种荧光pH敏感染料和一种在聚合物薄膜上使用该荧光pH敏感染料检测pH值的薄膜。含氟 pH 敏感染料包括具有磺酰基 (-SO2) 的芳基化合物和与芳基化合物的磺酰基 (-SO2) 共价键合的琼脂糖化合物。
• DYE COMPOUNDS
  申请人：SFC CO., LTD.

  公开号：US20180203015A1

  公开（公告）日：2018-07-19

  The present invention relates to dye compounds represented by Formulae I and II, which are described in the specification. The dye compounds of the present invention have markedly improved quantum yields and emit strong fluorescence compared to existing cyanine dyes. Due to these advantages, the dye compounds of the present invention can find applications in various fields, for example, as probes for various biological systems where optical imaging is required. Particularly, the dye compounds of the present invention can be used as mitotrackers capable of labeling and tracking mitochondria. Therefore, the dye compounds of the present invention can be used to quantitatively image mitochondria in live tissues and cells. Furthermore, the dye compounds of the present invention can be applied as pH probes for measuring the pH of live cells.