TATM, 1,3,4,6-Tetra-O-acetyl-2-O-triflyl-beta-D-mannopyranose

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: TATM, 1,3,4,6-Tetra-O-acetyl-2-O-triflyl-beta-D-mannopyranose
• 英文别名: [3,4,6-triacetyloxy-5-(trifluoromethylsulfonyloxy)oxan-2-yl]methyl acetate
• 化学式: C₁₅H₁₉F₃O₁₂S
• 分子量: 480.4
• InChiKey: OIBDVHSTOUGZTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  166
• 氢给体数：
  0
• 氢受体数：
  15

文献信息

• DIGITAL MICROFLUIDIC PLATFORM FOR RADIOCHEMISTRY
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20150203416A1

  公开（公告）日：2015-07-23

  Disclosed herein are methods of performing microchemical reactions and electro-wetting-on-dielectric devices (EWOD devices) for use in performing those reactions. These devices and method are particularly suited for preparing radiochemical compounds, particularly compounds containing 18 F.

  本文揭示了执行微化学反应的方法以及用于执行这些反应的电致润湿介电设备（EWOD设备）。这些设备和方法特别适用于制备放射化学化合物，尤其是含有18F的化合物。
• METHODS AND MATERIALS FOR FABRICATING MICROFLUIDIC DEVICES
  申请人：DeSimone Joseph M.

  公开号：US20090281250A1

  公开（公告）日：2009-11-12

  Materials and Methods are provided for fabricating microfluidic devices. The materials include low surface energy fluoropolymer compositions having multiple cure functional groups. The materials can include multiple photocurable and/or thermal-curable functional groups such that laminate devices can be fabricated. The materials also substantially do not swell in the presence of hydrocarbon solvents.
• METHOD FOR SYNTHESIZING RADIOPHARMACEUTICALS USING A CARTRIDGE
  申请人：Futurechem Co., LTD.

  公开号：US20150232392A1

  公开（公告）日：2015-08-20

  The present invention relates to a method for synthesizing a radiopharmaceutical using a cartridge, which makes it possible to carry out several steps of reaction required for synthesizing a radiopharmaceutical in the cartridge filled with a polymer. A method for synthesizing a radiopharmaceutical according to the present invention enables each step's reaction to be carried out with the solution confined in the cartridge so as not to flow out, thus being simplified compared to the conventional methods for synthesizing radiopharmaceuticals, and expediting the synthesis thereof.
• PROCESS FOR PRODUCING FLUORINATED COMPOUNDS USING ALCOHOL SOLVENT HAVING CARBONYL GROUP
  申请人：FUTURECHEM CO., LTD.

  公开号：US20190202820A1

  公开（公告）日：2019-07-04

  The present invention relates to a process for producing an organic fluoro compound containing [ 18 F]fluorine. The method of the present invention for producing the organic fluoro compound is not only advantageous for producing the organic fluoro compound with high yield by using the solvent represented by formula 1 for nucleophilic fluorination reaction but also suitable for automatic synthesis of 18 F-labeled radiopharmaceuticals due to the excellent solubility of the precursor compound in the solvent.
• Process for Producing Fluorinated Compounds Using Alcohol Solvent Having Unsaturated Hydrocarbon
  申请人：FUTURECHEM CO., LTD

  公开号：US20200407360A1

  公开（公告）日：2020-12-31

  The present invention relates to a process for producing an organofluoro compound including [ 18 F]fluorine, and by using a solvent represented by Formula 1 in nucleophilic fluorination reaction, an organofluoro compound may be prepared at a high yield. In addition, since the solvent has very excellent solubility for a precursor compound, the solvent is suitable for the automated synthesis of 18 F-labeled radiopharmaceuticals.