6-[2-[(9H-芴-9-甲氧基)羰基]肼基]-3-吡啶羧酸 | 444794-69-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 中文名称: 6-[2-[(9H-芴-9-甲氧基)羰基]肼基]-3-吡啶羧酸
• 英文名称: Fmoc-6-hydrazinoicotinic acid
• 英文别名: 6-(2-(((9H-Fluoren-9-yl)methoxy)carbonyl)hydrazinyl)nicotinic acid；6-[2-(9H-fluoren-9-ylmethoxycarbonyl)hydrazinyl]pyridine-3-carboxylic acid
• CAS: 444794-69-8
• 化学式: C₂₁H₁₇N₃O₄
• 分子量: 375.384
• InChiKey: SGOJASKAYXOQGD-UHFFFAOYSA-N

物化性质

• 密度：
  1.401±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  6

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  Fmoc-甘氨酸 、 Fmoc-L-缬氨酸 、 Fmoc-L-亮氨酸 、 Fmoc-L-丙氨酸 、 6-[2-[(9H-芴-9-甲氧基)羰基]肼基]-3-吡啶羧酸 、 Fmoc-L-脯氨酸 、 Fmoc-L-蛋氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 生成 6-hydrazinenicotinamide-GGMAPQRDTVGGRTTPPSWGPAKAQLRNSCA-NH2
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• [EN] POLYNUCLEOTIDE CONSTRUCTS HAVING DISULFIDE GROUPS<br/>[FR] CONSTRUCTIONS POLYNUCLÉOTIDIQUES CONTENANT DES GROUPES DISULFURE
  申请人：SOLSTICE BIOLOG LTD

  公开号：WO2015069932A1

  公开（公告）日：2015-05-14

  The invention features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components is attached to an internudeotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains one or more bulky groups proximal to the disulfide group. The invention also features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components (i) is attached to an internudeotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains at least 4 atoms in a chain between the disulfide linkage and the phosphorus atom of the internudeotide bridging group or the terminal group; and where the chain does not contain a phosphate, an amide, an ester, or an alkenylene. The invention also features methods of delivering a polynucleotide to a cell using the polynucleotide constructs of the invention.

  该发明涉及包含一个或多个组分（i）的聚核苷酸构造，其中每个一个或多个组分连接到聚核苷酸构造的一个核苷酸桥连基团或末端基团上，每个一个或多个组分（i）包含靠近二硫键的一个或多个臃肿基团。该发明还涉及包含一个或多个组分（i）的聚核苷酸构造，其中每个一个或多个组分（i）连接到聚核苷酸构造的一个核苷酸桥连基团或末端基团上，每个一个或多个组分（i）在二硫键和核苷酸桥连基团或末端基团的磷原子之间的链中至少包含4个原子；并且该链不包含磷酸酯、酰胺、酯或烯基烃。该发明还涉及使用该发明的聚核苷酸构造将聚核苷酸传递到细胞的方法。
• POLYNUCLEOTIDE CONSTRUCTS HAVING DISULFIDE GROUPS
  申请人：BRADSHAW Curt W.

  公开号：US20160257961A1

  公开（公告）日：2016-09-08

  The invention features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components is attached to an internucleotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains one or more bulky groups proximal to the disulfide group. The invention also features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components (i) is attached to an internucleotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains at least 4 atoms in a chain between the disulfide linkage and the phosphorus atom of the internucleotide bridging group or the terminal group; and where the chain does not contain a phosphate, an amide, an ester, or an alkenylene. The invention also features methods of delivering a polynucleotide to a cell using the polynucleotide constructs of the invention.

  本发明涉及一种聚核苷酸构建物，其包含一个或多个组分（i），该组分包含一个二硫键，其中每个组分中的一个或多个组分连接到聚核苷酸构建物的核苷酸桥接基团或末端基团上，并且每个组分（i）在二硫键附近包含一个或多个笨重基团。本发明还涉及一种聚核苷酸构建物，其包含一个或多个组分（i），该组分包含一个二硫键，其中每个组分中的一个或多个组分连接到聚核苷酸构建物的核苷酸桥接基团或末端基团上，并且每个组分（i）在二硫键和核苷酸桥接基团或末端基团的磷原子之间的链中至少含有4个原子；并且链中不含有磷酸盐、酰胺、酯或烯基烃。本发明还涉及使用本发明的聚核苷酸构建物向细胞传递聚核苷酸的方法。
• Dual mass spectrometry-cleavable crosslinking reagents for protein-protein interactions
  申请人：BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

  公开号：US10752655B2

  公开（公告）日：2020-08-25

  Described are dual mass-spectrometry-cleavable cross-linkers that can be cleaved selectively using two differential tandem mass-spectrometric techniques such as collision induced dissociation (CID) or electron transfer dissociation (ETD), i.e., a dual cleavable crosslinking technology (DUCCT) cross-linker. When used to cross-link a macromolecule, such as a peptide, MS/MS fragmentation produces two signature complementary mass spectra of same cross-linked peptides, the analysis of which gives rise to high confidence in characterizing the structures of the cross-linked macromolecules as well as sites of interactions. Also described, are methods of making and using DUCCT cross-linkers.

  所描述的是双质谱可裂解交联剂，这种交联剂可利用两种不同的串联质谱技术（如碰撞诱导解离（CID）或电子转移解离（ETD））选择性地裂解，即双可裂解交联技术（DUCCT）交联剂。当用于交联大分子（如肽）时，MS/MS 片段化会产生相同交联肽的两个特征互补质谱，对其进行分析可在表征交联大分子的结构和相互作用位点方面产生很高的可信度。此外，还介绍了制作和使用 DUCCT 交联剂的方法。
• Radiolabeled antibodies for treatment of tumors
  申请人：——

  公开号：US20040156780A1

  公开（公告）日：2004-08-12

  This invention provides methods for imaging and/or treating a tumor in a subject which comprise administering to the subject an amount of a radiolabeled antibody effective to image and/or treat the tumor, where the radiolabeled antibody binds to a cellular component released by dying tumor cells. This invention also provides methods for imaging and/or treating melanin-containing melanomas in a subject which comprise administering to the subject an amount of a radiolabeled anti-melanin antibody effective to image and/or treat the melanoma. The invention also provides compositions and methods of making compositions comprising radiolabeled antibodies for imaging and treating tumors, including melanin-containing melanomas.

  本发明提供了对受试者的肿瘤进行成像和/或治疗的方法，其中包括向受试者施用一定量的放射性标记抗体，该抗体能有效地对肿瘤进行成像和/或治疗，其中放射性标记抗体能与垂死肿瘤细胞释放的细胞成分结合。本发明还提供了对受试者体内含有黑色素的黑色素瘤进行成像和/或治疗的方法，该方法包括向受试者施用一定量的放射性标记抗黑色素抗体，该抗体对黑色素瘤的成像和/或治疗有效。本发明还提供了用于成像和治疗肿瘤（包括含黑色素的黑色素瘤）的包含放射性标记抗体的组合物和组合物的制造方法。
• INTERLEUKIN-8 LABELLED VIA ONE OR MORE SITE SPECIFICALLY CONJUGATED HYDRAZINONICOTINAMIDE (HYNIC) MOIETIES AND ITS USE IN DIAGNOSIS OF INFECTION AND INFLAMMATION
  申请人：Stichting Katholieke Universiteit

  公开号：EP1934251A2

  公开（公告）日：2008-06-25