2,3-Bis[(2-methylpropan-2-yl)oxy]butanedioic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,3-Bis[(2-methylpropan-2-yl)oxy]butanedioic acid
• 化学式: C₁₂H₂₂O₆
• 分子量: 262.3
• InChiKey: QRGSIFZGWPCQNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] CONVENIENT AND SCALABLE SYNTHESIS OF ETHYL N-[(2-BOC-AMINO) ETHYL] GLYCINATE AND ITS HYDROCHLORIDE SALT<br/>[FR] SYNTHESE PRATIQUE ET MODIFIABLE DE L'ETHYL N-[(2-BOC-AMINO) ETHYL] GLYCINATE ET DE SON CHLORHYDRATE
  申请人：UNIV WESTERN ONTARIO

  公开号：WO2004037772A1

  公开（公告）日：2004-05-06

  The present invention discloses an improved synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride salt. The synthesis is based on the reductive alkylation of Boc-ethylenediamine with ethyl glyoxylate hydrate and furnishes the title compound in near quantitative yield and high purity without chromatography. This compound is suitable, as is, for the synthesis peptide nucleic acid monomers. Further, conversion to the hydrochloride salt provides a stable, non-hygroscopic solid that is a convenient form for handling and storage.

  本发明公开了一种改进的合成乙基N-[(2-Boc-氨基)乙基]甘氨酸及其盐酸盐。该合成基于Boc-乙二胺与乙酰甘醇水合物的还原烷基化反应，并以接近定量产率和高纯度提供了标题化合物，无需色谱分离。该化合物适合直接用于合成肽核酸单体。此外，转化为盐酸盐提供了一种稳定的、不吸湿的固体形式，便于处理和储存。
• A COMPOUND FOR PREPARING POLYPEPTIDES
  申请人：Universität Wien

  公开号：EP3262058A1

  公开（公告）日：2018-01-03
• US6025503A
  申请人：——

  公开号：US6025503A

  公开（公告）日：2000-02-15
• [EN] A COMPOUND FOR PREPARING POLYPEPTIDES<br/>[FR] COMPOSÉ POUR LA PRÉPARATION DE POLYPEPTIDES
  申请人：UNIVERSITÄT WIEN

  公开号：WO2016135071A1

  公开（公告）日：2016-09-01

  The present invention relates to a compound comprising a protected or deprotected thiol moiety S enabling Native Chemical Ligation, a photolabile linker moiety L and at least one hydrophilic polymer moiety HP. Furthermore, the present invention relates to a method for production of a peptide conjugate P12 comprising a peptide moiety P1 and a second moiety P2 covalently bound with another via an amide bond, wherein the compound of the present invention employed for selectively forming the amide bond between P1 and P2.