2-benzylamino-3-benzyloxy-propan-1-ol | 170956-45-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzylamino-3-benzyloxy-propan-1-ol
• 英文别名: 2-(Benzylamino)-3-phenylmethoxypropan-1-ol
• CAS: 170956-45-3
• 化学式: C₁₇H₂₁NO₂
• 分子量: 271.359
• InChiKey: FPWIIVULJMZBDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-benzylamino-3-benzyloxy-propan-1-ol 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以99%的产率得到3-benzyl-4-benzyloxymethyl-2-oxo-1,2,3,-oxathiazolidine
  参考文献：
  名称：

  Nucleophilic ring opening of cyclic sulphamidites

  摘要：

  The cyclic sulphamidites (2S,4S)- and (2R,4S)-3-benzyl-4-benzyloxymethyl-2-oxo-1,2,3-oxathiazolidine 1 were prepared from S-glycidol in 60-66% overall yield. Nucleophilic ring opening of 1 by cyanide, azide and benzyloxy anions have been studied with respect to regio and stereospecificity. A mild procedure for benzylation of alcohols was introduced.

  DOI：

  10.1016/0957-4166(95)00211-7
• 作为产物：
  描述：

  2-噁唑烷酮,4-(羟甲基)-3-(苯基甲基)- 在 sodium hydroxide 、 sodium hydride 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-benzylamino-3-benzyloxy-propan-1-ol
  参考文献：
  名称：

  Nucleophilic ring opening of cyclic sulphamidites

  摘要：

  The cyclic sulphamidites (2S,4S)- and (2R,4S)-3-benzyl-4-benzyloxymethyl-2-oxo-1,2,3-oxathiazolidine 1 were prepared from S-glycidol in 60-66% overall yield. Nucleophilic ring opening of 1 by cyanide, azide and benzyloxy anions have been studied with respect to regio and stereospecificity. A mild procedure for benzylation of alcohols was introduced.

  DOI：

  10.1016/0957-4166(95)00211-7

文献信息

• HETEROCYCLIC INHIBITORS OF ATR KINASE
  申请人：Board of Regents, The University of Texas System

  公开号：US20190016713A1

  公开（公告）日：2019-01-17

  The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

  本公开涉及杂环化合物和方法，这些方法可能作为ATR激酶的抑制剂，用于治疗或预防癌症。
• Cationic ring-opening polymerization of <i>N</i>-benzylaziridines to polyamines <i>via</i> organic boron
  作者：Ge-Ge Gu、Tian-Jun Yue、Wei-min Ren

  DOI：10.1039/d2cc06817f

  日期：——

  reports the synthesis of cyclic polyamines via the cationic ring-opening polymerization (CROP) of N-benzylaziridines initiated by tris(pentafluorophenyl)borane. The debenzylation of these polyamines afforded water-soluble polyethylenimine derivatives. The electrospray ionization mass spectrometry and density functional theory results revealed that the CROP proceeded via the activated chain end intermediates

  该通讯报道了通过三（五氟苯基）硼烷引发的N-苄基氮丙啶的阳离子开环聚合 (CROP) 合成环状多胺。这些多胺的脱苄基化得到水溶性聚乙烯亚胺衍生物。电喷雾电离质谱和密度泛函理论结果表明，CROP通过活化的链端中间体进行。
• Heterocyclic inhibitors of ATR kinase
  申请人：Board of Regents, The University of Texas System

  公开号：US10392376B2

  公开（公告）日：2019-08-27

  The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

  本公开涉及可作为 ATR 激酶抑制剂用于治疗或预防癌症的杂环化合物和方法。
• Chelated complexes of paramagnetic metals with low toxicity
  申请人：BRACCO S.p.A.

  公开号：EP0872479B1

  公开（公告）日：2002-09-04
• US6149890A
  申请人：——

  公开号：US6149890A

  公开（公告）日：2000-11-21