1-(3'-acetamido-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole | 1146972-70-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3'-acetamido-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole
• 英文别名: N-[2-methoxy-5-(5-methoxy-3-methylindol-1-yl)sulfonylphenyl]acetamide
• CAS: 1146972-70-4
• 化学式: C₁₉H₂₀N₂O₅S
• 分子量: 388.444
• InChiKey: DKPMJCJQOFMQAF-UHFFFAOYSA-N

物化性质

• 密度：
  1.31±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  95
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(3'-acetamido-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 以3.6 g的产率得到1-(3'-amino-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole
  参考文献：
  名称：

  吲哚基磺酰胺类胺作为有效的和选择性的5-HT6受体拮抗剂的设计，合成和药理评价。

  摘要：

  一系列N'-[3-（吲哚-1-磺酰基）芳基] -N，N-二甲基乙烷-1,2-二胺和N'-[3-（吲哚-1-磺酰基）芳基] -N， N-二甲基丙烷-1,3-二胺被设计和合成为5-HT6受体配体。在基于功能报告基因的分析中筛选这些化合物时，它们显示出强大的拮抗活性，其Kb值在1.8-60 nM的范围内。铅化合物9y已显示出良好的ADME替代特性，可接受的药代动力学特征，并且在诸如新物体识别测试和莫里斯水迷宫等认知动物模型中具有活性。选择它进行详细分析。

  DOI：

  10.3109/14756366.2014.889126
• 作为产物：
  描述：

  2-乙酰氨基苯甲醚 在 氯磺酸 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 51.0h， 生成 1-(3'-acetamido-4'-methoxybenzenesulfonyl)-5-methoxy-3-methyl-1H-indole
  参考文献：
  名称：

  吲哚基磺酰胺类胺作为有效的和选择性的5-HT6受体拮抗剂的设计，合成和药理评价。

  摘要：

  一系列N'-[3-（吲哚-1-磺酰基）芳基] -N，N-二甲基乙烷-1,2-二胺和N'-[3-（吲哚-1-磺酰基）芳基] -N， N-二甲基丙烷-1,3-二胺被设计和合成为5-HT6受体配体。在基于功能报告基因的分析中筛选这些化合物时，它们显示出强大的拮抗活性，其Kb值在1.8-60 nM的范围内。铅化合物9y已显示出良好的ADME替代特性，可接受的药代动力学特征，并且在诸如新物体识别测试和莫里斯水迷宫等认知动物模型中具有活性。选择它进行详细分析。

  DOI：

  10.3109/14756366.2014.889126

文献信息

• [EN] AMINO ARYLSULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS FIELD OF INVENTION<br/>[FR] COMPOSÉS D'AMINOARYLSULFONAMIDE ET LEUR UTILISATION COMME LIGANDS DE 5-HT6
  申请人：SUVEN LIFE SCIENCES LTD

  公开号：WO2009053997A1

  公开（公告）日：2009-04-30

  The present invention relates to novel amino arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them: The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The compounds of the invention are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, obesity, anxiety, depression, diseases associated with pain, respiratory diseases, gastrointestinal, cardiovascular diseases and cancer.

  本发明涉及一种新型氨基芳基磺酰胺化合物的公式(I)，其衍生物，其立体异构体，其药学上可接受的盐以及含有它们的药学上可接受的组合物：本发明还涉及制备上述新型化合物、其衍生物、其立体异构体、其药学上可接受的盐以及含有它们的药学上可接受的组合物的方法。本发明的化合物在治疗与5-HT6受体功能相关的各种疾病方面具有用途。具体而言，本发明的化合物还可用于治疗各种中枢神经系统疾病、血液学疾病、进食障碍、肥胖、焦虑、抑郁、与疼痛有关的疾病、呼吸系统疾病、消化系统疾病、心血管疾病和癌症。
• AMINO ARYLSULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS
  申请人：Ramakrishna Nirogi Venkata Satya

  公开号：US20100216861A1

  公开（公告）日：2010-08-26

  The present invention relates to novel amino arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them: The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The compounds of the invention are useful in the treatment of various disorders that are related to 5-HT 6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, obesity, anxiety, depression, diseases associated with pain, respiratory diseases, gastrointestinal, cardiovascular diseases and cancer.

  本发明涉及一种新型氨基芳基磺酰胺化合物的公式（I），它们的衍生物，立体异构体，其药用可接受盐和含有它们的药用可接受组合物：本发明还涉及上述新型化合物的制备方法，它们的衍生物，立体异构体，其药用可接受盐和含有它们的药用可接受组合物。本发明的化合物在治疗与5-HT6受体功能相关的各种疾病方面具有用途。具体来说，本发明的化合物也在治疗各种中枢神经系统疾病，血液疾病，进食障碍，肥胖，焦虑，抑郁，与疼痛有关的疾病，呼吸系统疾病，胃肠道疾病，心血管疾病和癌症方面具有用途。
• Amino arylsulfonamide compounds and their use as 5-HT6 ligands
  申请人：Suven Life Sciences Limited

  公开号：US07964627B2

  公开（公告）日：2011-06-21

  The present invention relates to novel amino arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them: The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The compounds of the invention are useful in the treatment of various disorders that are related to 5-HT6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, obesity, anxiety, depression, diseases associated with pain, respiratory diseases, gastrointestinal, cardiovascular diseases and cancer.

  本发明涉及一种新的氨基芳基磺酰胺化合物的公式（I），它们的衍生物，立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物：本发明还涉及一种制备上述新化合物，其衍生物，立体异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物的过程。本发明的化合物在治疗与5-HT6受体功能相关的各种疾病方面有用。具体来说，本发明的化合物也在治疗各种中枢神经系统疾病，血液学疾病，饮食失调，肥胖，焦虑，抑郁，与疼痛相关的疾病，呼吸系统疾病，胃肠道，心血管疾病和癌症方面有用。
• AMINO ARYLSULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS FIELD OF INVENTION
  申请人：Suven Life Sciences Limited

  公开号：EP2200980B9

  公开（公告）日：2011-12-28
• US7964627B2
  申请人：——

  公开号：US7964627B2

  公开（公告）日：2011-06-21