(2R)-5-(1-aminoethylideneamino)-2-methylpentanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2R)-5-(1-aminoethylideneamino)-2-methylpentanoic acid
• 化学式: C₈H₁₆N₂O₂
• 分子量: 172.22
• InChiKey: LAKBWMPGYBNMJK-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  75.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Antimicrobial Peptidomimetics
  申请人：AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

  公开号：US20160333048A1

  公开（公告）日：2016-11-17

  The present invention relates to peptidomimetics of the formula (I) or (I)c wherein L 1 , L 2 , L 3 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , n, m, Q, X, Z 1 and Z 2 are defined as mentioned in the description and to salts and solvates of each of these compounds and to processes for the preparation thereof, compositions containing them and the uses of such compounds. It has been found that the compounds have a high microbicide activity and are suited to combat resistant bacteria, such as meticillin-resistant Staphylococcus aureus (MRSA) strains, at very low concentrations.