(2S)-2-[[4-(aminomethyl)cyclohexyl]amino]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-[[4-(aminomethyl)cyclohexyl]amino]propanoic acid
• 化学式: C₁₀H₂₀N₂O₂
• 分子量: 200.28
• InChiKey: IMAIRNKBENJRGS-UEJVZZJDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] MIRNA-485 INHIBITOR FOR HUNTINGTON'S DISEASE<br/>[FR] INHIBITEUR DE MIARN-485 POUR LA MALADIE DE HUNTINGTON
  申请人：BIORCHESTRA CO LTD

  公开号：WO2022003608A1

  公开（公告）日：2022-01-06

  The present disclosure includes the use of a miRNA inhibitor for treating a symptom or condition of Huntington's disease. The miRNA inhibitor useful for the present disclosure can inhibit miR-485 expression and/or activity, which in turn can modulate the level of proteins or gene expression related to Huntington's disease.

  本公开涉及使用miRNA抑制剂来治疗亨廷顿病的症状或状况。本公开所述的miRNA抑制剂可以抑制miR-485的表达和/或活性，从而可以调节与亨廷顿病相关的蛋白质或基因表达水平。
• MICELLAR NANOPARTICLES AND USES THEREOF
  申请人：Biorchestra Co., Ltd.

  公开号：EP3990028A1

  公开（公告）日：2022-05-04
• [EN] MICELLAR NANOPARTICLES AND USES THEREOF<br/>[FR] NANOPARTICULES MICELLAIRES ET UTILISATIONS ASSOCIÉES
  申请人：BIORCHESTRA CO LTD

  公开号：WO2020261227A1

  公开（公告）日：2020-12-30

  The present disclosure includes cationic carrier units comprising (i) a water soluble polymer, (ii) a positively charged carrier, and (iii) an adjuvant moiety, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an antisense oligonucleotide) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.
• [EN] MICELLAR NANOPARTICLES AND USES THEREOF<br/>[FR] NANOPARTICULES MICELLAIRES ET LEURS UTILISATIONS
  申请人：[en]BIORCHESTRA CO., LTD.

  公开号：WO2022144811A1

  公开（公告）日：2022-07-07

  The present disclosure includes cationic carrier units comprising (i) a water-soluble polymer, (ii) a positively charged carrier, (iii) a hydrophobic moiety, and (iv) a crosslinking moiety, wherein when the cationic carrier unit is mixed with an anionic payload (e.g., an antisense oligonucleotide) that electrostatically interacts with the cationic carrier unit, the resulting composition self-organizes into a micelle encapsulating the anionic payload in its core. The cationic carrier units can also comprise a tissue specific targeting moiety, which would be displayed on the surface of the micelle. The disclosure also includes micelles comprising the cationic carrier units of the disclosure, methods of manufacture of cationic carrier units and micelles, pharmaceutical compositions comprising the micelles, and also methods of treating diseases or conditions comprising administering the micelles to a subject in need thereof.