alpha-Succinimidosuccinimide | 69556-95-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: alpha-Succinimidosuccinimide
• 英文别名: 1-(2,5-dioxopyrrolidin-3-yl)pyrrolidine-2,5-dione
• CAS: 69556-95-2
• 化学式: C₈H₈N₂O₄
• 分子量: 196.16
• InChiKey: FJUZJOJINPUTGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  83.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Engineered chimeric pegylated ADI and methods of use
  申请人：TDW Group

  公开号：US10463721B2

  公开（公告）日：2019-11-05

  Provided are chimeric arginine deiminases, including pegylated chimeric arginine deiminases, and related compositions and methods of use thereof, including methods of treating cancer.

  本文提供了嵌合型精氨酸脱氨酶（包括聚乙二醇化嵌合型精氨酸脱氨酶）及其相关组合物和使用方法，包括治疗癌症的方法。
• Arginine deiminase with reduced cross-reactivity toward ADI - PEG 20 antibodies for cancer treatment
  申请人：Polaris Group

  公开号：US11235037B2

  公开（公告）日：2022-02-01

  The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20 (pegylated ADI derived from M. hominis), but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer.

  本发明一般涉及分离到的精氨酸脱氨酶（ADI）蛋白，与ADI-PEG 20（来源于M.hominis的聚乙二醇化ADI）相比，该蛋白与抗ADI-PEG 20抗体的交叉反应性降低，但其功能特性可与ADI-PEG 20媲美或优于ADI-PEG 20，本发明还涉及包含ADI蛋白的组合物，以及治疗精氨酸依赖性疾病或相关疾病（如癌症）的相关方法。
• Polymer having charged units
  申请人：Hughes Charles Timothy

  公开号：US20050228120A1

  公开（公告）日：2005-10-13

  A polymer comprising one or more macromonomer units selected from the group consisting of polysiloxane, perfluoroalkylpolyether (PFPE), fluorinated poly(meth)acrylate, polyalkyl (meth)acrylate, polyolefin and fluorinated polyolefin, and one or more charged units (such as an anionic, cationic or zwitter-ionic monomer), formed from a polymerization medium containing an aqueous solution of charged units and use of this polymer as an intraocular lens for the implantation into or onto the cornea. Another aspects relates to a process for coating the above polymer with an adhesive comprising covalently coupling co-reactive surface functional groups of a natural or synthetic polymer with functional groups present (or introduced) on the surface of the macromonomer containing polymer, followed by covalently coupling a multifunctionally activated compound having at least one functional group that is co-reactive to the reactive groups of the natural or synthetic polymer.

  由一种或多种大单体单元组成的聚合物，这些大单体单元选自由聚硅氧烷、全氟烷基聚醚（PFPE）、氟化聚（甲基）丙烯酸酯、聚烷基（甲基）丙烯酸酯、聚烯烃和氟化聚烯烃组成的组、和一种或多种带电单元（如阴离子、阳离子或齐聚物离子单体），由含有带电单元水溶液的聚合介质形成，并将这种聚合物用作植入角膜或角膜上的眼内透镜。另一个方面涉及用粘合剂涂覆上述聚合物的工艺，包括将天然或合成聚合物的共反应表面官能团与存在于（或引入）含大单体聚合物表面的官能团共价偶联，然后共价偶联具有至少一个与天然或合成聚合物的反应基团共反应的官能团的多功能活化化合物。
• Biomedical adhesive
  申请人：Hughes Charles Timothy

  公开号：US20050238692A1

  公开（公告）日：2005-10-27

  The biomedical adhesives of the invention provide a reactive surface to adhere or crosslink to tissue and may be used, for example, as ready-to-use corneal onlay in ophthalmic surgery. The invention provides a method for bonding a bulk material to a corresponding nucleophilic or electrophilic surface including attaching a multifunctionally activated bulk material compound to the bulk material and contacting a functional group of the compound with the surface under conditions permitting covalent linkage between the bulk material and the functional group.

  本发明的生物医学粘合剂提供了一个反应性表面，可粘附或交联到组织上，例如可用作眼科手术中的即用型角膜镶嵌物。本发明提供了一种将块状材料粘合到相应的亲核或亲电表面的方法，包括将多功能活化的块状材料化合物附着到块状材料上，并在允许块状材料和官能团共价连接的条件下将化合物的官能团与表面接触。
• Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
  申请人：Daniloff Y. George

  公开号：US20050281883A1

  公开（公告）日：2005-12-22

  Crosslinkable compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. In one embodiment, a first component has nucleophilic groups and a second component has electrophilic groups. Additional components may have nucleophilic or electrophilic groups. Methods for preparing and using the compositions are also provided as are kits for delivery of the compositions. Exemplary uses for the crosslinked compositions include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.

  可交联组合物易于原位交联，从而提供交联生物材料。这种组合物至少含有两种生物相容性、非免疫原性的成分，这些成分上具有活性基团，所选的官能团可使这些成分之间发生相互反应，即交联。在一个实施方案中，第一种成分具有亲核基团，第二种成分具有亲电基团。其他成分也可能具有亲核或亲电基团。此外，还提供了制备和使用组合物的方法，以及用于提供组合物的试剂盒。交联组合物的示例用途包括组织增强、生物活性剂递送、生物粘附以及防止手术或损伤后的粘连。