(3,5-Dichlorophenyl) 5-pyridin-2-ylthiophene-2-sulfonate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: (3,5-Dichlorophenyl) 5-pyridin-2-ylthiophene-2-sulfonate
• 化学式: C₁₅H₉Cl₂NO₃S₂
• 分子量: 386.3
• InChiKey: SNYLEHZXPWMUTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  92.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• RAC1 inhibitors of neurofibroma formation
  申请人：Indiana University Research and Technology Corporation

  公开号：US10314831B2

  公开（公告）日：2019-06-11

  Small molecule inhibitor compounds for inhibiting Rac1 activity and their use for treating, preventing, or reducing the incidences of malignant and nonmalignant manifestations, e.g., plexiform neurofibromas that occur in subjects suffering from neurofibromatosis type 1 (NF1) are disclosed.

  本研究公开了用于抑制 Rac1 活性的小分子抑制剂化合物及其在治疗、预防或降低恶性和非恶性表现（如神经纤维瘤病 1 型（NF1）患者发生的丛状神经纤维瘤）的发病率方面的用途。
• RAC1 INHIBITORS OF NEUROFIBROMA FORMATION
  申请人：INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

  公开号：US20160317516A1

  公开（公告）日：2016-11-03

  Small molecule inhibitor compounds for inhibiting Rac 1 activity and their use for treating, preventing, or reducing the incidences of malignant and nonmalignant manifestations, e.g., plexiform neurofibromas that occur in subjects suffering from neurofibromatosis type 1 (NF1) are disclosed.
• [EN] RAC1 INHIBITORS OF NEUROFIBROMA FORMATION<br/>[FR] INHIBITEURS DE RAC1 UTILISÉS DANS LA FORMATION DE NEUROFIBROME
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2015108966A2

  公开（公告）日：2015-07-23

  Small molecule inhibitor compounds for inhibiting Rac1 activity and their use for treating, preventing, or reducing the incidences of malignant and nonmalignant manifestations, e.g., plexiform neurofibromas that occur in subjects suffering from neurofibromatosis type 1 (NF1) are disclosed.