Octadeca-9,12-dienyl carbamate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Octadeca-9,12-dienyl carbamate
• 英文别名: octadeca-9,12-dienyl carbamate
• 化学式: C₁₉H₃₅NO₂
• 分子量: 309.5
• InChiKey: DCTVJXBEMKSQMC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  22
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] NOVEL BIS-NITROGEN CONTAINING CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY<br/>[FR] NOUVEAUX LIPIDES CATIONIQUES CONTENANT DU BIS-AZOTE POUR ADMINISTRATION D'OLIGONUCLÉOTIDE
  申请人：MERCK SHARP & DOHME

  公开号：WO2013016058A1

  公开（公告）日：2013-01-31

  The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy and tolerability. The present invention employs bis-nitrogen containing cationic lipids to enhance the efficiency and tolerability of in vivo delivery of siRNA.