3-acetamido-N,N'-dimethylpentanediamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-acetamido-N,N'-dimethylpentanediamide
• 化学式: C₉H₁₇N₃O₃
• 分子量: 215.25
• InChiKey: HCFYIEKQOZPXJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  87.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Conjugates of an anti-TNF-alpha antibody
  申请人：Nektar Therapeutics

  公开号：US10232042B2

  公开（公告）日：2019-03-19

  Conjugates of an anti-TNF antibody and one or more nonpeptidic water-soluble polymers are provided. Typically, the nonpeptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.

  本研究提供了抗肿瘤坏死因子抗体与一种或多种非肽水溶性聚合物的共轭物。通常，非肽水溶性聚合物是聚乙二醇或其衍生物。除其他外，还提供了包含共轭物的组合物、制造共轭物的方法以及向患者施用组合物的方法。
• Conjugates of an IL-2 moiety and a polymer
  申请人：Nektar Therapeutics

  公开号：US10960079B2

  公开（公告）日：2021-03-30

  Conjugates of an interleukin-2 (“IL-2”) moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the non-peptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.

  提供了白细胞介素-2（"IL-2"）分子与一种或多种非肽水溶性聚合物的共轭物。通常，非肽水溶性聚合物是聚乙二醇或其衍生物。除其他外，还提供了包含共轭物的组合物、制造共轭物的方法、向个体施用组合物的方法、核酸序列、表达系统、宿主细胞和制备IL-moieties的方法。
• Method of refolding an interleukin-2 (IL-2) protein
  申请人：Nektar Therapeutics

  公开号：US11091525B2

  公开（公告）日：2021-08-17

  Conjugates of an interleukin-2 (“IL-2”) moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the non-peptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.

  提供了白细胞介素-2（"IL-2"）分子与一种或多种非肽水溶性聚合物的共轭物。通常，非肽水溶性聚合物是聚乙二醇或其衍生物。除其他外，还提供了包含共轭物的组合物、制造共轭物的方法、向个体施用组合物的方法、核酸序列、表达系统、宿主细胞和制备IL-moieties的方法。
• Method of making a water-soluble polymer-factor VIII moiety conjugate
  申请人：Nektar Therapeutics

  公开号：US11141465B2

  公开（公告）日：2021-10-12

  Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.

  提供了因子 VIII 分子与一种或多种水溶性聚合物的共轭物。通常，水溶性聚合物是聚乙二醇或其衍生物。此外，还提供了包含该共轭物的组合物、制造该共轭物的方法以及向患者施用包含该共轭物的组合物的方法。
• CONJUGATES OF AN IL-15 MOIETY AND A POLYMER
  申请人：Nektar Therapeutics

  公开号：US20170035898A1

  公开（公告）日：2017-02-09

  Conjugates of an IL-15 moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to an individual.