[(5-Ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-quinolin-4-ylmethyl] cyclopropanecarboxylate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: [(5-Ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-quinolin-4-ylmethyl] cyclopropanecarboxylate
• 化学式: C₂₃H₂₆N₂O₂
• 分子量: 362.5
• InChiKey: LZEIKPVKWHAHNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS
  申请人：PainCeptor Pharma Corp.

  公开号：EP1734962A2

  公开（公告）日：2006-12-27
• Compositions and methods for modulating gated ion channels
  申请人：Babinski Kazimierz

  公开号：US20070004680A1

  公开（公告）日：2007-01-04

  The present invention relates to compositions and methods to modulate the activity of gated ion channels.
• [EN] COMPOSITIONS AND METHODS FOR MODULATING GATED ION CHANNELS<br/>[FR] COMPOSITIONS ET METHODES DE MODULATION DES CANAUX IONIQUES COMMANDES PAR PORTE
  申请人：PAINCEPTOR PHARMA CORP

  公开号：WO2006038070A2

  公开（公告）日：2006-04-13

  The present application relates to compositions which modulate the activity of gated ion channels. This provide an effect in the treatment of pain, inflammatory disorders and neurological disorders. Preferred compounds include quinine or quinidine derivatives with the hydroxyl at the nine position being esterified with an aliphatic carboxylic acid, optionally bearing an additional cycloalkyl ring on the chain. The gated ion channels modulated include homomultimeric and heteromultimeric gates.