7-[[Bis(2-hydroxyethyl)amino]methyl]-1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 7-[[Bis(2-hydroxyethyl)amino]methyl]-1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol
• 化学式: C21H25N3O6
• 分子量: 415.4
• InChiKey: KSVDDBXZHXNBGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• SERUM-FREE EXPANSION OF CELLS IN CULTURE
  申请人：Choongwae Pharma Corporation

  公开号：EP1960777A2

  公开（公告）日：2008-08-27
• Serum-free expansion of cells in culture
  申请人：Kahn Michael

  公开号：US20070128669A1

  公开（公告）日：2007-06-07

  Methods and agents are disclosed for modulating the interaction of β-catenin or γ-catenin with CBP or p300. Agents that increase the binding of CBP to β-catenin are associated with enhancing the β-catenin-related proliferation of adult stem cells, including hematopoietic stem cells, neural stem cells, skin stem cells, and pancreatic stem cells, as well as embryonic stem cells.
• [EN] SERUM-FREE EXPANSION OF CELLS IN CULTURE<br/>[FR] EXPANSION SANS SERUM DE CELLULES EN CULTURE
  申请人：INST CHEMICAL GENOMICS

  公开号：WO2007062243A2

  公开（公告）日：2007-05-31

  (EN) Methods and agents are disclosed for modulating the interaction of &bgr;-catenin or ϝ-catenin with CBP or p300. Agents that increase the binding of CBP to &bgr;-catenin are associated with enhancing the &bgr;-catenin related proliferation of adult stem cells, including hematopoietic stem cells, neural stem cells, skin stem cells, and pancreatic stem cells, as well as embryonic stem cells.(FR) L'invention porte sur des méthodes et des agents modulant l'interaction de la ß-caténine ou de la ?-caténine avec le CBP ou le p300. Les agents renforçant la fixation du CBP sur la ß-caténine sont associés à un accroissement lié à la ß-caténine de la prolifération de cellules souches adultes dont: les cellules souches hématopoïétiques, les cellules souches neurales, les cellules souches de la peau, les cellules souches du pancréas, ainsi que les cellules souches embryonnaires.