N1-(4-methoxy)phenylpropyl-biguanide | 36397-25-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N1-(4-methoxy)phenylpropyl-biguanide
• 英文别名: 1-(Diaminomethylidene)-2-[3-(4-methoxyphenyl)propyl]guanidine
• CAS: 36397-25-8
• 化学式: C₁₂H₁₉N₅O
• 分子量: 249.316
• InChiKey: JQCYFUGTMMBOGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  112
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• [EN] GUANIDINE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS DE GUANIDINE ET LEUR UTILISATION
  申请人：HANALL BIOPHARMA CO LTD

  公开号：WO2015160220A1

  公开（公告）日：2015-10-22

  The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.

  本发明涉及用于抑制线粒体氧化磷酸化（OXPHOS）的胍啉化合物及其使用。更具体地，本发明涉及一种用于预防或治疗与OXPHOS相关的疾病，特别是通过抑制线粒体氧化磷酸化和重编程细胞代谢的药物组合物。
• Biguanide compound and use thereof
  申请人：ImmunoMet Therapeutics Inc.

  公开号：US10626085B2

  公开（公告）日：2020-04-21

  The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis.

  本发明涉及一种胍类化合物及其用途，更具体地说，涉及一种在抑制癌细胞增殖、癌症转移和癌症复发方面具有卓越效果的胍类衍生物；其制备方法；以及一种以其为有效成分的药物组合物。与现有药物相比，根据本发明的胍类衍生物即使剂量很小，也能显示出极佳的抑制癌细胞增殖、癌转移和癌症复发的效果，因此可有效用于预防或治疗各种癌症，如子宫癌、乳腺癌、胃癌、脑癌、直肠癌、大肠癌、肺癌、皮肤癌、血癌、肝癌等，抑制癌细胞增殖和癌转移。
• BIGUANIDE COMPOUND AND USE THEREOF
  申请人：Immunomet Therapeutics Inc.

  公开号：EP3222614B1

  公开（公告）日：2020-07-29
• GUANIDINE COMPOUNDS AND USE THEREOF
  申请人：IMMUNOMET THERAPEUTICS INC.

  公开号：US20170073331A1

  公开（公告）日：2017-03-16

  The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer, by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.
• [EN] BIGUANIDE COMPOUND AND USE THEREOF<br/>[FR] COMPOSÉ DE BIGUANIDE ET UTILISATION DE CELUI-CI<br/>[KO] 바이구아나이드 화합물 및 이의 용도
  申请人：IMMUNOMET THERAPEUTICS INC

  公开号：WO2016080810A2

  公开（公告）日：2016-05-26

  본 발명은 구아니딘 화합물 및 이의 용도에 관한 것으로서, 더욱 자세하게는 암세포 증식 억제, 암 전이와 암 재발을 억제에 우수한 효과를 나타내는 구아니딘 유도체, 이의 제조 방법 및 이를 유효성분으로 함유하는 약학적 조성물에 관한 것이다. 본 발명에 따른 구아니딘 유도체는 기존 약물에 비해 적은 복용량으로도 우수한 암세포 증식 억제 및 암 전이와 재발 억제 효과를 나타내며, 따라서 자궁암, 유방암, 위암, 뇌암, 직장암, 대장암, 폐암, 피부암, 혈액암 및 간암 등의 다양한 암의 예방 또는 치료, 암세포의 증식 억제, 및 암전이 억제에 유용하게 이용될 수 있다.