6-十五烷基水杨酸乙酯 | 217449-10-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 6-十五烷基水杨酸乙酯
• 英文名称: ethyl 6-pentadecylsalicylate
• 英文别名: 2-hydroxy-6-pentadecyl-benzoic acid ethyl ester；2-Hydroxy-6-pentadecyl-benzoesaeure-aethylester；Cyclogallipharsaeure-aethylester；Ethyl 2-hydroxy-6-pentadecylbenzoate
• CAS: 217449-10-0
• 化学式: C₂₄H₄₀O₃
• 分子量: 376.58
• InChiKey: TZAKXMHDMYUDJC-UHFFFAOYSA-N

物化性质

• 沸点：
  479.1±33.0 °C(Predicted)
• 密度：
  0.966±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.2
• 重原子数：
  27
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-十五烷基水杨酸乙酯 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以81.1%的产率得到氢化白果酸
  参考文献：
  名称：

  Synthesis of Anacardic Acids Utilizing an Annelation Reaction of Isoxazoles with Ethyl Acetoacetate.

  摘要：

  腰果酚酸，即6-十五烷基水杨酸（1）和6-[8(Z)-十五烯基]水杨酸（2），通过与乙酰乙酸乙酯的环化反应从异恶唑合成得到。

  DOI：

  10.1248/cpb.46.1501
• 作为产物：
  描述：

  溴代十五烷 在 六甲基磷酰三胺 、 正丁基锂 、 diiron nonacarbonyl 、 盐酸羟胺 、 水 作用下， 以 乙醇 、 水 、 苯 为溶剂， 反应 2.67h， 生成 6-十五烷基水杨酸乙酯
  参考文献：
  名称：

  Synthesis of Anacardic Acids Utilizing an Annelation Reaction of Isoxazoles with Ethyl Acetoacetate.

  摘要：

  腰果酚酸，即6-十五烷基水杨酸（1）和6-[8(Z)-十五烯基]水杨酸（2），通过与乙酰乙酸乙酯的环化反应从异恶唑合成得到。

  DOI：

  10.1248/cpb.46.1501

文献信息

• Improved Synthesis of Anacardic Acids, 6-Pentadecylsalicylic Acid and 6-(8(Z)-Pentadecenyl)salicylic Acid, from Aldehyde and Acetoacetate.
  作者：Mitsuru SATOH、Naoki TAKEUCHI、Takashi FUJITA、Katsuya YAMAZAKI、Tsuyoshi NISHIMURA、Seisho TOBINAGA

  DOI：10.1248/cpb.47.1115

  日期：——

  Anacardic acids, 6-pentadecadienylsalicylic acid and 6-[8(Z)-pentadecatrienyl]salicylic acid were synthesized from aldehyde and acetoacetate with 1, 2-addition.

  从醛和乙酰乙酸酯通过1,2加成反应合成了阿那卡酸、6-十五碳二烯基水杨酸和6-[8(Z)-十五碳三烯基]水杨酸。
• Pillay, Journal of the Indian Chemical Society, 1935, vol. 12, p. 231,234
  作者：Pillay

  DOI：——

  日期：——
• Differences in normal values for murine white blood cell counts and other hematological parameters based on sampling site
  作者：J. A. Nemzek、G. L. Bolgos、B. A. Williams、D. G. Remick

  DOI：10.1007/pl00000229

  日期：2001.10

  Objective and design: The effect of blood sampling site on the hemogram and neutrophil adhesion molecules was examined in BALB/c mice.Materials and methods: Blood samples were drawn from the tail, eye, and heart during anesthesia with ketamine and xylazine. Cell numbers were quantified with an automated counter and flow cytometry was used to quantify CD11b and CD18.Results: Total white blood cell (WBC) counts were highest from tail, lower from eye, and significantly lower from heart blood. In general, differences between tail and heart counts reflected changes in all cell types. RBCs, platelets and hematocrits were significantly increased in tail compared to heart blood. Although CD18 levels were not different, CD11b was significantly higher on neutrophils from tail compared to heart blood.Conclusions: In anesthetized BALB/c mice, sampling site readily influences blood counts and neutrophil CD11b. The findings underscore the need to standardize sampling site when measuring these parameters.
• Synthesis of Anacardic Acids Utilizing an Annelation Reaction of Isoxazoles with Ethyl Acetoacetate.
  作者：Mitsuru SATOH、Naoki TAKEUCHI、Takeshi FUJITA、Katsuya YAMAZAKI、Seisho TOBINAGA

  DOI：10.1248/cpb.46.1501

  日期：——

  Anacardic acids, 6-pentadecylsalicylic acid (1) and 6-[8(Z)-pentadecenyl]salicylic acid (2) were synthesized from isoxazoles by annelation reactions with ethyl acetoacetate.

  腰果酚酸，即6-十五烷基水杨酸（1）和6-[8(Z)-十五烯基]水杨酸（2），通过与乙酰乙酸乙酯的环化反应从异恶唑合成得到。