6-十八炔腈 | 56600-19-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 6-十八炔腈
• 英文名称: octadec-6-ynenitrile
• 英文别名: Octadec-6-innitril；6-Octadecynenitrile
• CAS: 56600-19-2
• 化学式: C₁₈H₃₁N
• 分子量: 261.451
• InChiKey: NPUREDFPSYXSQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  19
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  塔日酸 在 氨 、 水 、 phosphorus pentoxide 、 三氯化磷 作用下， 生成 6-十八炔腈
  参考文献：
  名称：

  Elevation of plasma fatty acids by ten-hour intralipid infusion has no effect on basal or glucose-stimulated insulin secretion in normal man

  摘要：

  There is controversy over the effect of free fatty acids (FFAs) on insulin secretion. Previous studies have shown opposite effects of short- and long-term exposure to elevated concentrations of FFAs. We studied 8 normal subjects (mean age, 30 years; mean body mass index, 23.4 kg/m(2)) on 2 occasions. Each had a 10-hour overnight infusion of Intralipid 20% (Pharmacia, Milton Keynes, UK) with simultaneous infusion of heparin (0.4 U/kg body weight/min) or a control infusion of saline (150 mmol/L). Insulin secretion was assessed immediately after completion of the 10-hour infusion by an intravenous glucose tolerance test. Results were analyzed using paired t tests. Intralipid infusion caused an increase in plasma FFAs of more than 9-fold (P <.01), with a simultaneous increase in glycerol (P <.01) and hydroxybutyrate (P <.01). There was no difference in blood glucose concentrations during the infusion or intravenous glucose tolerance test. Similarly, insulin secretion was not significantly different during Intralipid infusion or in the intravenous glucose tolerance test (peak insulin achieved in glucose tolerance test, P =.51; total insulin secretion during intravenous glucose tolerance test, P =.27). In conclusion, after increasing plasma FFA concentrations over g-fold during a 10-hour infusion of Intralipid and heparin, we found no difference in basal or glucose-stimulated insulin secretion. Copyright (C) 2000 by W.B. Saunders Company.

  DOI：

  10.1016/s0026-0495(00)80007-4

文献信息

• Elevation of plasma fatty acids by ten-hour intralipid infusion has no effect on basal or glucose-stimulated insulin secretion in normal man
  作者：Caroline M. Amery、Rachel A. Round、Janet M. Smith、Malcolm Nattrass

  DOI：10.1016/s0026-0495(00)80007-4

  日期：2000.4

  There is controversy over the effect of free fatty acids (FFAs) on insulin secretion. Previous studies have shown opposite effects of short- and long-term exposure to elevated concentrations of FFAs. We studied 8 normal subjects (mean age, 30 years; mean body mass index, 23.4 kg/m(2)) on 2 occasions. Each had a 10-hour overnight infusion of Intralipid 20% (Pharmacia, Milton Keynes, UK) with simultaneous infusion of heparin (0.4 U/kg body weight/min) or a control infusion of saline (150 mmol/L). Insulin secretion was assessed immediately after completion of the 10-hour infusion by an intravenous glucose tolerance test. Results were analyzed using paired t tests. Intralipid infusion caused an increase in plasma FFAs of more than 9-fold (P <.01), with a simultaneous increase in glycerol (P <.01) and hydroxybutyrate (P <.01). There was no difference in blood glucose concentrations during the infusion or intravenous glucose tolerance test. Similarly, insulin secretion was not significantly different during Intralipid infusion or in the intravenous glucose tolerance test (peak insulin achieved in glucose tolerance test, P =.51; total insulin secretion during intravenous glucose tolerance test, P =.27). In conclusion, after increasing plasma FFA concentrations over g-fold during a 10-hour infusion of Intralipid and heparin, we found no difference in basal or glucose-stimulated insulin secretion. Copyright (C) 2000 by W.B. Saunders Company.