5-[2-[2-[2-[[1-Amino-6-[(4-aminobenzoyl)amino]-1-oxohexan-2-yl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-[[4-carboxy-4-[[2-[2-[2-[4-[(3,3,5,5-tetramethyl-6-sulfohexanoyl)sulfamoyl]butanoylamino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]-5-oxopentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-[2-[2-[2-[[1-Amino-6-[(4-aminobenzoyl)amino]-1-oxohexan-2-yl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-[[4-carboxy-4-[[2-[2-[2-[4-[(3,3,5,5-tetramethyl-6-sulfohexanoyl)sulfamoyl]butanoylamino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]-5-oxopentanoic acid
• 英文别名: 5-[2-[2-[2-[[1-amino-6-[(4-aminobenzoyl)amino]-1-oxohexan-2-yl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-[[4-carboxy-4-[[2-[2-[2-[4-[(3,3,5,5-tetramethyl-6-sulfohexanoyl)sulfamoyl]butanoylamino]ethoxy]ethoxy]acetyl]amino]butanoyl]amino]-5-oxopentanoic acid
• 化学式: C₄₉H₈₁N₉O₂₁S₂
• 分子量: 1196.3
• InChiKey: REQIALCZDNWEQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  81
• 可旋转键数：
  45
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  490
• 氢给体数：
  12
• 氢受体数：
  22

文献信息

• GROWTH HORMONES WITH PROLONGED IN-VIVO EFFICACY
  申请人：Novo Nordisk Health Care AG

  公开号：EP2525834B1

  公开（公告）日：2019-07-17
• Growth Hormones with Prolonged In-Vivo Efficacy
  申请人：Novo Nordisk HealthCare AG

  公开号：US20170239362A1

  公开（公告）日：2017-08-24

  The invention relates to growth hormone compounds with a protracted profile. The effect is obtained by linking an albumin binding residue via a hydrophilic spacer to growth hormone variants. Further described are methods of preparing and using such compounds. These growth hormone compounds are based on there althered profile considered particular useful in therapy.