5-Cyclohexyl-2,3-dimethylpyrazin | 73570-41-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-Cyclohexyl-2,3-dimethylpyrazin
• 英文别名: 5-cyclohexyl-2,3-dimethylpyrazine
• CAS: 73570-41-9
• 化学式: C₁₂H₁₈N₂
• 分子量: 190.288
• InChiKey: MWUHQBQXXYRDHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,3-二甲基-5-羟基吡嗪 在 吡啶 、 1,3-bis[(diphenylphosphino)propane]dichloronickel(II) 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 14.5h， 生成 5-Cyclohexyl-2,3-dimethylpyrazin
  参考文献：
  名称：

  Regioselective Synthesis of Trialkylpyrazines via Nickel-Catalyzed Negishi Cross-Coupling of Pyrazine Triflate

  摘要：

  A regioselective synthesis of trialkylpyrazines via nickel-catalyzed cross-coupling reaction of pyrazine triflate is reported. The 5-substituted 2,3-dimethylpyrazine derivatives including trail pheromone components of the ant Eutetramorium mocquerysi have been successfully synthesized in good yields by nickel-catalyzed Negishi cross-coupling reactions of pyrazine triflate mediated by alkyl and arylzinc halides.

  DOI：

  10.1055/s-0031-1290972

文献信息

• FLAMENT I.; SONNAY PH.; OHLOFF G., BULL. SOC. CHIM. BELG., 1979, 88, NO 11, 941-950
  作者：FLAMENT I.、 SONNAY PH.、 OHLOFF G.

  DOI：——

  日期：——
• MASUDA HIDEKI; TANAKA MASATA; AKIYAMA TAKUYA; SHIBAMOTO TAKAYUKI, J. AGR. AND FOOD CHEM., 1980, 28, NO 2, 244-246
  作者：MASUDA HIDEKI、 TANAKA MASATA、 AKIYAMA TAKUYA、 SHIBAMOTO TAKAYUKI

  DOI：——

  日期：——
• Sun Dehua, Cai Songchuan, Zhao Toonan, Bao Yanchu, Huaxue shiji (Chem. Reagents), 15 (1993) N 1, S 37-39
  作者：Sun Dehua, Cai Songchuan, Zhao Toonan, Bao Yanchu

  DOI：——

  日期：——
• Regioselective Synthesis of Trialkylpyrazines via Nickel-Catalyzed Negishi Cross-Coupling of Pyrazine Triflate
  作者：Kee-In Lee、Arigala Pitchaiah、In Hwang、Jin-Soo Hwang、Hyungrok Kim

  DOI：10.1055/s-0031-1290972

  日期：2012.6

  A regioselective synthesis of trialkylpyrazines via nickel-catalyzed cross-coupling reaction of pyrazine triflate is reported. The 5-substituted 2,3-dimethylpyrazine derivatives including trail pheromone components of the ant Eutetramorium mocquerysi have been successfully synthesized in good yields by nickel-catalyzed Negishi cross-coupling reactions of pyrazine triflate mediated by alkyl and arylzinc halides.