(3S)-1-methylpyrrolidine-3-thiol | 206117-29-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (3S)-1-methylpyrrolidine-3-thiol
• CAS: 206117-29-5
• 化学式: C₅H₁₁NS
• 分子量: 117.215
• InChiKey: PGMDHKAOJGGKIU-YFKPBYRVSA-N

物化性质

• 沸点：
  146.3±33.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  4.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (3S)-1-methylpyrrolidine-3-thiol 、 5'-O-(苄基磺酰基)-2',3'-O-异亚丙基腺苷 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors

  摘要：

  Potent SAH analogues with constrained homocysteine units have been designed and synthesized as inhibitors of human DNMT enzymes. The five membered (2S,4S)-4-mercaptopyrrolidine-2-carboxylic acid, in 1a, was a good replacement for homocysteine, while the corresponding six-member counterpart was less active. Further optimization of 1a, changed the selectivity pro. le of these inhibitors. A Chloro substituent at the 2-position of 1a, compound 1d, retained potency against DNMT1, while N-6 alkylation, compound 7a, conserved DNMT3b2 activity. The concomitant substitutions of 1a at both 2- and N-6 positions reduced activity against both enzymes. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.132
• 作为产物：
  描述：

  S-[(3S)-1-methylpyrrolidin-3-yl] ethanethioate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 0.25h， 生成 (3S)-1-methylpyrrolidine-3-thiol
  参考文献：
  名称：

  Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors

  摘要：

  Potent SAH analogues with constrained homocysteine units have been designed and synthesized as inhibitors of human DNMT enzymes. The five membered (2S,4S)-4-mercaptopyrrolidine-2-carboxylic acid, in 1a, was a good replacement for homocysteine, while the corresponding six-member counterpart was less active. Further optimization of 1a, changed the selectivity pro. le of these inhibitors. A Chloro substituent at the 2-position of 1a, compound 1d, retained potency against DNMT1, while N-6 alkylation, compound 7a, conserved DNMT3b2 activity. The concomitant substitutions of 1a at both 2- and N-6 positions reduced activity against both enzymes. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.132

文献信息

• A method for the efficient evaluation of substrate-based cholinesterase imaging probes for Alzheimer’s disease
  作者：Sultan Darvesh、Scott Banfield、Maeve Dufour、Katrina L. Forrestall、Hillary Maillet、G. Andrew Reid、Dane Sands、Ian R. Pottie

  DOI：10.1080/14756366.2023.2225797

  日期：2023.12.31

  evaluated using enzyme kinetic and KR methods. Spectrophotometric methods demonstrated all thioesters were ChE substrates, yet only a few provided staining in the brain with the KR method. Esters were ChE substrates with interactions with brain ChEs. These results suggest that the KR method may provide an efficient means to screen compounds as probes for imaging AD-associated ChEs.

  抽象的 胆碱酯酶 (ChE) 已被确定为阿尔茨海默病 (AD) 的诊断标志物。已合成基于底物的探针来检测 ChE，但尚未检测到与 AD 病理相关的 ChE 分布变化。通常使用分光光度法和纯酶来筛选探针的特异性和动力学。然而，与 AD 病理相关的 ChE 的生化特性发生了改变。目前的工作是确定卡诺夫斯基根 (KR) 组织化学方法是否可用于评估病理部位的探针。合成了 30 种硫酯和酯，并使用酶动力学和 KR 方法进行了评估。分光光度法证明所有硫酯都是 ChE 底物，但只有少数硫酯通过 KR 方法在大脑中提供染色。酯是与脑 ChE 相互作用的 ChE 底物。这些结果表明 KR 方法可能提供一种有效的方法来筛选化合物作为 AD 相关 ChE 成像的探针。
• ——
  作者：LEONARD C. A.、 FRANKO B. V.、 CALE A. D., JR.

  DOI：——

  日期：——