(2S)-2-(dimethylamino)-3-methyl-N-[(2S)-3-methyl-1-oxobutan-2-yl]butanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-(dimethylamino)-3-methyl-N-[(2S)-3-methyl-1-oxobutan-2-yl]butanamide
• 化学式: C₁₂H₂₄N₂O₂
• 分子量: 228.33
• InChiKey: GCYIUVXHAKPYJK-MNOVXSKESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] PROTEIN-POLYMER-DRUG CONJUGATES AND METHODS OF USING SAME<br/>[FR] CONJUGUÉS MÉDICAMENT-PROTÉINE-POLYMÈRE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：MERSANA THERAPEUTICS INC

  公开号：WO2015195925A1

  公开（公告）日：2015-12-23

  A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders, such as cancer in a subject having low HER2 expression with the conjugates or their compositions are also described.