16-[2-[2,3-Di(hexadecanoyloxy)propoxy-hydroxyphosphoryl]oxyethylamino]hexadecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 16-[2-[2,3-Di(hexadecanoyloxy)propoxy-hydroxyphosphoryl]oxyethylamino]hexadecanoic acid
• 化学式: C₉H₉O₂Pol
• 分子量: 946.4
• InChiKey: LVXGYPQBVIGODB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.8
• 重原子数：
  65
• 可旋转键数：
  56
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  158
• 氢给体数：
  3
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  16-[2-[2,3-Di(hexadecanoyloxy)propoxy-hydroxyphosphoryl]oxyethylamino]hexadecanoic acid 、 在 N-羟基-7-氮杂苯并三氮唑 、 碳酸氢钠 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 生成 2-(4-Methoxyphenyl)pyrano[2,3-g][1,3]benzothiazol-7-one
  参考文献：
  名称：

  Solid-supported ortho-iodoarylboronic acid catalyst for direct amidation of carboxylic acids

  摘要：

  Amides are a ubiquitous class of organic compounds endowed with great utility. There is a need for simple and effective catalytic methods for their direct formation from carboxylic acids and amines as a way to avoid the use of coupling reagents. We have designed a recyclable resin-supported derivative of 5-methoxy-2-iodophenylboronic acid as a heterogeneous catalyst active in ambient conditions for promoting direct amidations of aliphatic carboxylic acids and amines. The optimal, practical procedure involves a simple double-filtration to isolate the amide product while separating the catalyst from residual molecular sieves. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.06.043
• 作为产物：
  描述：

  1,2-二棕榈酰-外消旋-甘油-3-磷酰乙醇胺 、 15-formylpentadecanoic acid 在 吡啶 、 sodium cyanoborohydride 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 3.0h， 生成 16-[2-[2,3-Di(hexadecanoyloxy)propoxy-hydroxyphosphoryl]oxyethylamino]hexadecanoic acid
  参考文献：
  名称：

  Lipids and lipid assemblies comrising transfection enhancer elements

  摘要：

  使用包含一种或多种脂质和一种或多种转染增强元素（“TEE”）的脂质组装体，用于体内、体外或离体细胞转染，其中所述脂质具有一般式（I），所述转染增强元素具有一般式（II）。pH敏感的亲水元素可以位于脂质和TEE之间的链接远端或TEE内部的中心位置。最好，pH敏感的亲水元素包括pKa在2到6之间的弱酸。

  公开号：

  EP1938843A1

文献信息

• Lipids and lipid assemblies comrising transfection enhancer elements
  申请人：novosom AG

  公开号：EP1938843A1

  公开（公告）日：2008-07-02

  Use of lipid assemblies comprising one or more lipids with one or more transfection enhancer elements ("TEE") for the in vivo, in vitro or ex-vivo transfection of cells wherein said lipids have the general formula (I) and said transfection enhancer elements have the general formula (II). The pH sensitive hydrophilic element may be located distally from the link between the lipid and the TEE or centrally within the TEE. Preferably, the pH sensitive hydrophilic element comprises weak acids having a pKa of between 2 and 6.

  使用包含一种或多种脂质和一种或多种转染增强元素（“TEE”）的脂质组装体，用于体内、体外或离体细胞转染，其中所述脂质具有一般式（I），所述转染增强元素具有一般式（II）。pH敏感的亲水元素可以位于脂质和TEE之间的链接远端或TEE内部的中心位置。最好，pH敏感的亲水元素包括pKa在2到6之间的弱酸。
• Novel Dihydropyrimidine Derivatives And Their Use As Anti-Cancer Agents
  申请人：Lopez Roman

  公开号：US20080145453A1

  公开（公告）日：2008-06-19

  The invention concerns molecules of formula (I), drugs containing same and their use as anti-cancer agents.

  本发明涉及公式(I)的分子，含有该分子的药物以及它们作为抗癌剂的使用。
• Solid-supported ortho-iodoarylboronic acid catalyst for direct amidation of carboxylic acids
  作者：Nicolas Gernigon、Hongchao Zheng、Dennis G. Hall

  DOI：10.1016/j.tetlet.2013.06.043

  日期：2013.8

  Amides are a ubiquitous class of organic compounds endowed with great utility. There is a need for simple and effective catalytic methods for their direct formation from carboxylic acids and amines as a way to avoid the use of coupling reagents. We have designed a recyclable resin-supported derivative of 5-methoxy-2-iodophenylboronic acid as a heterogeneous catalyst active in ambient conditions for promoting direct amidations of aliphatic carboxylic acids and amines. The optimal, practical procedure involves a simple double-filtration to isolate the amide product while separating the catalyst from residual molecular sieves. (C) 2013 Elsevier Ltd. All rights reserved.
• Lipids and lipid assemblies comprising transfection enhancer elements
  申请人：Panzner Steffen

  公开号：US20080145413A1

  公开（公告）日：2008-06-19

  This disclosure describes structural elements that enhance fusogenicity of lipids and lipid assemblies (e.g. liposomes) with biological membranes, in particular cell membranes, and use of such structures. The elements are pH sensitive in terms of charge and hydrophilicity and undergo a polar—apolar transition when exposed to low pH.

  本公开描述了增强脂质和脂质组装物（例如脂质体）与生物膜，特别是细胞膜融合性的结构元素，以及这些结构的应用。这些元素在电荷和亲水性方面对pH敏感，并在暴露于低pH时经历极性-非极性转变。