7-[(3-Hydroxypropylamino)methyl]-1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 7-[(3-Hydroxypropylamino)methyl]-1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol
• 化学式: C20H23N3O5
• 分子量: 385.4
• InChiKey: WGRMFPXFECGWNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• SERUM-FREE EXPANSION OF CELLS IN CULTURE
  申请人：Choongwae Pharma Corporation

  公开号：EP1960777A2

  公开（公告）日：2008-08-27
• Serum-free expansion of cells in culture
  申请人：Kahn Michael

  公开号：US20070128669A1

  公开（公告）日：2007-06-07

  Methods and agents are disclosed for modulating the interaction of β-catenin or γ-catenin with CBP or p300. Agents that increase the binding of CBP to β-catenin are associated with enhancing the β-catenin-related proliferation of adult stem cells, including hematopoietic stem cells, neural stem cells, skin stem cells, and pancreatic stem cells, as well as embryonic stem cells.
• [EN] SERUM-FREE EXPANSION OF CELLS IN CULTURE<br/>[FR] EXPANSION SANS SERUM DE CELLULES EN CULTURE
  申请人：CHOONGWAE PHARMA CORP

  公开号：WO2007062243A9

  公开（公告）日：2008-12-04

  [EN] Methods and agents are disclosed for modulating the interaction of ß-catenin or ?-catenin with CBP or p300. Agents that increase the binding of CBP to ß-catenin are associated with enhancing the ß-catenin related proliferation of adult stem cells, including hematopoietic stem cells, neural stem cells, skin stem cells, and pancreatic stem cells, as well as embryonic stem cells.
  [FR] L'invention porte sur des méthodes et des agents modulant l'interaction de la ß-caténine ou de la ?-caténine avec le CBP ou le p300. Les agents renforçant la fixation du CBP sur la ß-caténine sont associés à un accroissement lié à la ß-caténine de la prolifération de cellules souches adultes dont: les cellules souches hématopoïétiques, les cellules souches neurales, les cellules souches de la peau, les cellules souches du pancréas, ainsi que les cellules souches embryonnaires.