2.3-Dimethoxybenzoylazid | 56475-31-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2.3-Dimethoxybenzoylazid
• 英文别名: 2,3-Dimethoxybenzoyl azide
• CAS: 56475-31-1
• 化学式: C₉H₉N₃O₃
• 分子量: 207.189
• InChiKey: JIPPPHPSIVNPTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2.3-Dimethoxybenzoylazid 在 三乙胺 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 21.0h， 生成 N-(2,3-二甲氧基苯基)乙酰胺
  参考文献：
  名称：

  Acetamidoquinone and acetamidohydroxy derivatives as inhibitors for both dihydroxyacetamido epoxidase and dehydrogenase

  摘要：

  A series of monohydroxy and dihydroxyacetanilides, acetamidoquinones and bromoacetamidoquinones have been synthesised and tested as substrates and/or inhibitors of highly purified dihydroxyacetamido epoxidase (DHAE) and dihydroxy acetamido dehydrogenase (DHADH) from Streptomyces LL-C10337. None was found to act as substrates but many selectively inhibit the enzymes. Kinetic analysis has shown that all the compounds act as reversible competitive inhibitors with respect to the substrates 2,5-dihydroxyacetanilide and 2,3-epoxy-1,4-benzoquinone-5-acetanilide. Monohydroxy acetanilides. showed weak inhibition to these enzymes compared to the dihydroxy derivatives while the more powerful inhibitors were the benzoquinoneacetanilide and its 5-bromo equivalent. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00403-5
• 作为产物：
  描述：

  2,3-二甲氧基苯甲酸 在 四丁基溴化铵 氯化亚砜 、 sodium azide 作用下， 以 二氯甲烷 、 水 、 苯 为溶剂， 反应 2.0h， 生成 2.3-Dimethoxybenzoylazid
  参考文献：
  名称：

  二甲氧基和三甲氧基[1]苯并噻吩并[2,3- c ]喹啉的合成

  摘要：

  通过将合适的3-氯-N-苯基苯并[ b ]噻吩-2-甲酰胺15-17光环化为[1]苯并噻吩并[2，] ，制备了三个二甲氧基[1]苯并噻吩并[2,3- c ]喹啉24-26。 3- ç ]喹啉6（5 ħ） -酮18-20，接着氯化，以6-氯[1]苯并噻吩并[2,3- c ^〕喹啉21-23，然后，获得标题化合物脱氯。的反应24-26用甲基碘提供的相应Ñ -甲基季盐27-29。甲醇钠易于转化21-23到三甲氧基[1]苯并噻吩并[2,3- c ]喹啉30-32。

  DOI：

  10.1002/jhet.5570240617

文献信息

• The synthesis of dimethoxy- and trimethoxy[1]benzothieno[2,3-<i>c</i>]quinolines
  作者：John G. Stuart、Shinya Khora、J. Dew McKenney、Raymond N. Castle

  DOI：10.1002/jhet.5570240617

  日期：1987.11

  Three dimethoxy[1]benzothieno[2,3-c]quinolines 24–26 were prepared by photocyclization of the appropriate 3-chloro-N-phenylbenzo[b]thiophene-2-carboxamides 15–17 to [1]benzothieno[2,3-c]quinolin-6(5H)-ones 18–20 followed by chlorination to 6-chloro[1]benzothieno[2,3-c]quinolines 21–23 and then dechlorination resulting in the title compounds. Reaction of 24–26 with methyl iodide furnished the corresponding

  通过将合适的3-氯-N-苯基苯并[ b ]噻吩-2-甲酰胺15-17光环化为[1]苯并噻吩并[2，] ，制备了三个二甲氧基[1]苯并噻吩并[2,3- c ]喹啉24-26。 3- ç ]喹啉6（5 ħ） -酮18-20，接着氯化，以6-氯[1]苯并噻吩并[2,3- c ^〕喹啉21-23，然后，获得标题化合物脱氯。的反应24-26用甲基碘提供的相应Ñ -甲基季盐27-29。甲醇钠易于转化21-23到三甲氧基[1]苯并噻吩并[2,3- c ]喹啉30-32。
• Collins,D.J. et al., Australian Journal of Chemistry, 1975, vol. 28, p. 673 - 679
  作者：Collins,D.J. et al.

  DOI：——

  日期：——
• SUNDARAM M. G., J. LABELLED COMPOUNDS AND RADIOPHARM., 1981, 18, NO 4, 489-494
  作者：SUNDARAM M. G.

  DOI：——

  日期：——
• Acetamidoquinone and acetamidohydroxy derivatives as inhibitors for both dihydroxyacetamido epoxidase and dehydrogenase
  作者：Chris G. Whiteley

  DOI：10.1016/s0968-0896(01)00403-5

  日期：2002.5

  A series of monohydroxy and dihydroxyacetanilides, acetamidoquinones and bromoacetamidoquinones have been synthesised and tested as substrates and/or inhibitors of highly purified dihydroxyacetamido epoxidase (DHAE) and dihydroxy acetamido dehydrogenase (DHADH) from Streptomyces LL-C10337. None was found to act as substrates but many selectively inhibit the enzymes. Kinetic analysis has shown that all the compounds act as reversible competitive inhibitors with respect to the substrates 2,5-dihydroxyacetanilide and 2,3-epoxy-1,4-benzoquinone-5-acetanilide. Monohydroxy acetanilides. showed weak inhibition to these enzymes compared to the dihydroxy derivatives while the more powerful inhibitors were the benzoquinoneacetanilide and its 5-bromo equivalent. (C) 2002 Elsevier Science Ltd. All rights reserved.