4-[2-[(1S)-1-carboxy-2-phenylethyl]iminohydrazinyl]benzoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[2-[(1S)-1-carboxy-2-phenylethyl]iminohydrazinyl]benzoic acid
• 化学式: C₁₆H₁₅N₃O₄
• 分子量: 313.31
• InChiKey: LKFLRFXMXGRFQR-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• LIGHT-SWITCHABLE POLYPEPTIDE AND USES THEREOF
  申请人：TECHNISCHE UNIVERSITÄT MÜNCHEN

  公开号：US20210079037A1

  公开（公告）日：2021-03-18

  The present invention relates to a light-switchable polypeptide. In particular, the present invention relates to a polypeptide comprising a light-responsive element, wherein the configuration (i.e. the configurational state) of the light-responsive element can be switched between a trans and cis isomer by irradiating the polypeptide with (a) particular wavelength(s) of light, and wherein the switch of said configuration alters the conformation and binding activity of said polypeptide to a ligand (e.g. molecule of interest). Also, the present invention comprises using said light-switchable polypeptide for isolating and/or purifying a molecule of interest. The present invention further provides an affinity matrix, an affinity chromatography column, and an affinity chromatography apparatus comprising the light-switchable polypeptide of the invention.