2-(4-fluorophenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(pyridin-3-ylmethyl)-2H-pyrrol-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 2-(4-fluorophenyl)-4-hydroxy-3-(5-methylfuran-2-carbonyl)-1-(pyridin-3-ylmethyl)-2H-pyrrol-5-one
• 化学式: C₂₂H₁₇FN₂O₄
• 分子量: 392.4
• InChiKey: XSRKCTJRXUFBJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  83.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US11136409B2

  公开（公告）日：2021-10-05

  The present invention is based, in part, on the identification of novel USP10 biomarkers and modulators, and methods of use thereof, for identifying, assessing, preventing, and treating AML.

  本发明部分基于新型 USP10 生物标记物和调节剂的鉴定及其使用方法，用于鉴定、评估、预防和治疗急性髓细胞白血病。
• COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF AML USING USP10 BIOMARKERS AND MODULATORS
  申请人：BUHRLAGE Sara

  公开号：US20190202929A1

  公开（公告）日：2019-07-04

  The present invention is based, in part, on the identification of novel USP10 biomarkers and modulators, and methods of use thereof, for identifying, assessing, preventing, and treating AML.
• [EN] COMPOSITIONS AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF AML USING USP10 BIOMARKERS AND MODULATORS<br/>[FR] COMPOSITIONS ET MÉTHODES POUR L'IDENTIFICATION, L'ÉVALUATION, LA PRÉVENTION ET LE TRAITEMENT DE LA LMA AU MOYEN DE BIOMARQUEURS USP10 ET DE MODULATEURS
  申请人：DANA FARBER CANCER INST INC

  公开号：WO2018057618A1

  公开（公告）日：2018-03-29

  The present invention is based, in part, on the identification of novel USP10 biomarkers and modulators, and methods of use thereof, for identifying, assessing, preventing, and treating AML.