N-Acetamido-maleinimid | 20311-07-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-Acetamido-maleinimid
• 英文别名: N-(Acetyl-amino)-maleinsaeure-imid；N-(2,5-dioxopyrrol-1-yl)acetamide
• CAS: 20311-07-3
• 化学式: C₆H₆N₂O₃
• 分子量: 154.125
• InChiKey: WEZIYLYVEZPIMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-Acetyl-2-(3-carboxy-acryloyl)-hydrazin 在 溶剂黄146 作用下， 生成 N-Acetamido-maleinimid
  参考文献：
  名称：

  Maleic Hydrazide. I. Reactions with Selected Electrophilic Reagents¹

  摘要：

  DOI：

  10.1021/ja01554a074

文献信息

• Method of producing labeled antibody
  申请人：FURUKAWA ELECTRIC CO., LTD.

  公开号：US10466234B2

  公开（公告）日：2019-11-05

  A method of producing a labeled antibody, including the steps of: a) allowing silica nanoparticles containing a functional molecule and having a thiol group on a surface thereof, and a linker molecule containing a maleimido group and an amino group, to coexist in a solvent to form a thioether bond between the thiol group and the maleimido group, thereby obtaining functional molecule-containing silica nanoparticles on which the linker molecule is bonded; and b) allowing the functional molecule-containing silica nanoparticles on which the linker molecule is bonded, carbodiimide and an antibody to coexist in an aqueous solvent to form an amide bond between the amino group of the linker molecule and a carboxyl group of the antibody.

  一种生产标记抗体的方法，包括以下步骤 a) 让含有功能分子并在其表面具有硫醇基的二氧化硅纳米粒子和含有马来酰亚胺基和氨基的连接分子在溶剂中共存，以在硫醇基和马来酰亚胺基之间形成硫醚键，从而获得含有功能分子的二氧化硅纳米粒子，并在其上键合连接分子；以及 b) 使键合有连接体分子的含功能分子的二氧化硅纳米粒子、碳化二亚胺和抗体在水性溶剂中共存，以在连接体分子的氨基和抗体的羧基之间形成酰胺键。
• PARNAROUSKIS M.; RUBINSTEIN H., J. HETEROCYCL. CHEM. <JHTC-AD>, 1976, 13, NO 3, 423-426
  作者：PARNAROUSKIS M.、 RUBINSTEIN H.

  DOI：——

  日期：——
• METHOD OF PRODUCING LABELED ANTIBODY
  申请人：Furukawa Electric Co., Ltd.

  公开号：EP2952895B1

  公开（公告）日：2018-01-10
• METHOD AND APPARATUS FOR MOVING STAGE DETECTION OF SINGLE MOLECULAR EVENTS
  申请人：Battulga Nasanshargal

  公开号：US20080241951A1

  公开（公告）日：2008-10-02

  An apparatus and method based on the apparatus is disclosed for detecting and monitoring chemical and/or bio-chemical reactions or interactions at the single molecule level, where detection and monitoring is improved by moving the viewing field of the detector in a controlled manner. The motion of the moving frame is accomplished either through software in the detector system or is accomplished by moving the reacting system. The motion is controlled and is either linear, circular or elliptical. The motion provides for improved site identification or mapping, improved event detection and monitoring, improved signal recognition and improved noise reduction.
• Maleic Hydrazide. I. Reactions with Selected Electrophilic Reagents¹
  作者：Henry Feuer、Harry Rubinstein

  DOI：10.1021/ja01554a074

  日期：1958.11