4-hydroxy-2-phenyl-1-(1,3,4-thiadiazol-2-yl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 4-hydroxy-2-phenyl-1-(1,3,4-thiadiazol-2-yl)-3-(thiophene-2-carbonyl)-2H-pyrrol-5-one
• 化学式: C₁₇H₁₁N₃O₃S₂
• 分子量: 369.4
• InChiKey: UITRBHYSXMGGNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  140
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Screening methods for identifying specific Staphylococcus aureus inhibitors
  申请人：Guenther Richard H.

  公开号：US10316371B2

  公开（公告）日：2019-06-11

  Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.

  本文描述了抑制金黄色葡萄球菌繁殖的方法和筛选抑制金黄色葡萄球菌繁殖的化合物的方法。一种抑制金黄色葡萄球菌繁殖的方法包括抑制或稳定金黄色葡萄球菌中特定金黄色葡萄球菌 tRNA 的核糖体结合，其抑制量足以抑制金黄色葡萄球菌蛋白质的表达。筛选可抑制金黄色葡萄球菌繁殖的化合物的方法包括将特异的金黄色葡萄球菌tRNA与核糖体接触，该核糖体在试验化合物和编码蛋氨酸和精氨酸（即包括序列AUGAGA）的mRNA存在的情况下结合该tRNA，然后确定该化合物是否抑制该tRNA的结合。
• SCREENING METHODS FOR IDENTIFYING SPECIFIC STAPHYLOCOCCUS AUREUS INHIBITORS
  申请人：Guenther Richard H.

  公开号：US20140163037A1

  公开（公告）日：2014-06-12

  Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.
• [EN] SCREENING METHODS FOR IDENTIFYING SPECIFIC STAPHYLOCOCCUS AUREUS INHIBITORS<br/>[FR] PROCÉDÉS DE CRIBLAGE POUR L'IDENTIFICATION D'INHIBITEURS SPÉCIFIQUES DE STAPHYLOCCOCUS AUREUS
  申请人：TRANA DISCOVERY INC

  公开号：WO2012135416A1

  公开（公告）日：2012-10-04

  Methods of inhibiting S. aureus propagation, and screening for compounds that inhibit S. aureus propagation, are described. A method of inhibiting S. aureus propagation comprises either inhibiting or stabilizing ribosomal binding of a specific S. aureus tRNA in the S. aureus by an amount sufficient to inhibit S. aureus protein expression. A method of screening for compounds useful for inhibiting S. aureus propagation comprises contacting a specific S. aureus tRNA to a ribosome that binds that tRNA in the presence of the test compound and an mRNA that codes for methionine and arginine (i.e., includes the sequence AUGAGA), and then determining whether the compound inhibits the binding of that tRNA.