1-isopropoxy-6,6,7,7-tetrafluoro-4-oxaheptan-2-ol | 1024024-66-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-isopropoxy-6,6,7,7-tetrafluoro-4-oxaheptan-2-ol
• 英文别名: 1-Isopropoxy-6,6,7,7-tetrafluoro-4-oxaheptan-2-ol；1-propan-2-yloxy-3-(2,2,3,3-tetrafluoropropoxy)propan-2-ol
• CAS: 1024024-66-5
• 化学式: C₉H₁₆F₄O₃
• 分子量: 248.218
• InChiKey: VKKQCAVEAGBCLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3-(2,2,3,3-四氟丙氧基)-1,2-氧化丙烯 、 异丙醇 在 sodium 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 以75%的产率得到1-isopropoxy-6,6,7,7-tetrafluoro-4-oxaheptan-2-ol
  参考文献：
  名称：

  碱性介质中含氟缩水甘油醚与醇反应的特征

  摘要：

  The reaction of fluorine-containing glycidyl ethers with various alcohols (i-PrOH, MeOH, PhOH, 2,2,3,3-tetrafluoropropanol) in basic medium resulted in products of regioselective opening of the oxirane ring. In reaction of 2,2,3,3-tetrafluoropropyloxymethyloxirane with 2-propanol under conditions of phase-transfer catalysis the main product was the corresponding 1,2-diol (yield 42%).

  DOI：

  10.1134/s1070428007050041

文献信息

• Features of reaction between fluorine-containing glycidyl ethers and alcohols in basic medium
  作者：D. N. Bazhin、T. I. Gorbunova、A. Ya. Zapevalov、V. E. Kirichenko、V. I. Saloutin

  DOI：10.1134/s1070428007050041

  日期：2007.5

  The reaction of fluorine-containing glycidyl ethers with various alcohols (i-PrOH, MeOH, PhOH, 2,2,3,3-tetrafluoropropanol) in basic medium resulted in products of regioselective opening of the oxirane ring. In reaction of 2,2,3,3-tetrafluoropropyloxymethyloxirane with 2-propanol under conditions of phase-transfer catalysis the main product was the corresponding 1,2-diol (yield 42%).