The present invention provides a multivalent compound for targeted molecular imaging and/or targeted drug delivery, wherein two components or targeting molecules each interacts with one or more biomarkers on a cell. The present invention further provides a multifunctional chelator to combine the targeting molecules. The present invention also provides an in vitro high-throughput screening assay to determine the length of the spacer molecules. The present invention also relates to compounds/probes, kits and methods for use in targeted molecular imaging and/or targeted drug delivery.
本发明提供了一种用于靶向分子成像和/或靶向药物传递的多价化合物,其中两个组分或靶向分子分别与细胞上的一个或多个
生物标志物相互作用。本发明还提供了一种多功能
螯合剂来结合这些靶向分子。本发明还提供了一种体外高通量筛选测定法来确定间隔分子的长度。本发明还涉及用于靶向分子成像和/或靶向药物传递的化合物/探针、试剂盒和方法。