Tert-butyl 2-[[4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylcarbamoyl]phenyl]methyl-(4-methoxyphenyl)sulfonylamino]-3-methylbutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tert-butyl 2-[[4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylcarbamoyl]phenyl]methyl-(4-methoxyphenyl)sulfonylamino]-3-methylbutanoate
• 英文别名: tert-butyl 2-[[4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylcarbamoyl]phenyl]methyl-(4-methoxyphenyl)sulfonylamino]-3-methylbutanoate
• 化学式: C32H47N5O9S
• 分子量: 677.8
• InChiKey: GYCGTJWKAJKXHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  47
• 可旋转键数：
  23
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  152
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• Diagnostic imaging agents with mmp inhibitory activity
  申请人：Storey Anthony

  公开号：US20070071670A1

  公开（公告）日：2007-03-29

  The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.

  本发明涉及诊断成像领域。具体来说，该发明涉及已知涉及特定基质金属蛋白酶的疾病的诊断成像。该发明的一个实施例是一种具有适用于诊断成像的基质金属蛋白酶抑制活性的化合物。本发明还揭示了一种包含该发明的诊断成像试剂的药物组合物，其适合于哺乳动物的给药形式。此外，该发明还揭示了用于合成该发明的诊断成像试剂的中间体以及用于制备该发明的药物组合物的试剂盒。该发明的药物组合物可用于诊断已知涉及特定基质金属蛋白酶的疾病。
• US8231858B2
  申请人：——

  公开号：US8231858B2

  公开（公告）日：2012-07-31