4-(3,3-Dimethylcyclohepta-1,4,6-trien-1-yl)sulfonylmorpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(3,3-Dimethylcyclohepta-1,4,6-trien-1-yl)sulfonylmorpholine
• 英文别名: 4-(3,3-dimethylcyclohepta-1,4,6-trien-1-yl)sulfonylmorpholine
• 化学式: C₁₃H₁₉NO₃S
• 分子量: 269.36
• InChiKey: TWIVFRIBQUJFSU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] NOVEL FERROPORTIN INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE LA FERROPORTINE
  申请人：VIFOR (INTERNATIONAL) AG

  公开号：WO2017068089A2

  公开（公告）日：2017-04-27

  The invention relates to novel ferroportin inhibitors of the general formula (I) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.