5-chloro-N-[1-cyclohexyl-2-oxo-2-[4-[1-(pyrrolidin-1-ylmethyl)cyclopropyl]anilino]ethyl]thiophene-2-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-chloro-N-[1-cyclohexyl-2-oxo-2-[4-[1-(pyrrolidin-1-ylmethyl)cyclopropyl]anilino]ethyl]thiophene-2-carboxamide
• 化学式: C₂₇H₃₄ClN₃O₂S
• 分子量: 500.1
• InChiKey: LCUNRHSSOGABKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  89.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• AMIDE COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP3018123A1

  公开（公告）日：2016-05-11

  The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

  本发明涉及具有 RORγt 抑制作用的化合物 (I) 或其盐。式（I）中，各符号如说明书中所定义。
• Amide compound
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US10472376B2

  公开（公告）日：2019-11-12

  The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

  本发明涉及具有 RORγt 抑制作用的化合物 (I) 或其盐。式（I）中，各符号如说明书中所定义。
• Heterocyclic amide compounds having RORyT inhibitory action
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US11053262B2

  公开（公告）日：2021-07-06

  The present invention relates to compound (I) or a salt thereof which has a RORγt inhibitory action. In the formula (I), each symbol is as defined in the specification.

  本发明涉及具有 RORγt 抑制作用的化合物 (I) 或其盐。式（I）中，各符号如说明书中所定义。
• ROR GAMMA T INHIBITORS AND TOPICAL USES THEREOF
  申请人：Dermira, Inc

  公开号：EP4054712A2

  公开（公告）日：2022-09-14
• ROR Gamma T Inhibitors and Topical Uses Thereof
  申请人：Dermira, inc.

  公开号：US20220409643A1

  公开（公告）日：2022-12-29

  The present disclosure is directed to use of RORγt inhibitors in the treatment of autoimmune disorders, e.g., autoimmune disorders of the skin. This disclosure is also directed to pharmaceutical compositions comprising an RORγt inhibitor and a pharmaceutically acceptable carrier for topical administration.