8-Methoxy-4,7-dimethyl-chroman-2-ol | 1026097-11-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 8-Methoxy-4,7-dimethyl-chroman-2-ol
• 英文别名: 8-methoxy-4,7-dimethyl-3,4-dihydro-2H-chromen-2-ol
• CAS: 1026097-11-9
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: NUCBLINRDJNOPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-Methoxy-4,7-dimethyl-chroman-2-ol 在 potassium tert-butylate 、 potassium carbonate 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 19.0h， 生成 (5Z)-5-[3-(2,3-dimethoxy-4-methylphenyl)butylidene]-4-methylfuran-2-one
  参考文献：
  名称：

  A new approach to the pseudopterosins using an arene alkylation with a γ-methylene-γ-butyrolactone

  摘要：

  A short and practical route to the tricyclic core of an unnatural pseudopterosin diastereoisomer is presented. Key features are an arene alkylation with a gamma -methylene-gamma -butyrolactone, viz. 10 --> 14, and an elaborate reduction sequence 14 --> 17 which both proceed diastereoselectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)02207-3
• 作为产物：
  描述：

  3-甲基苯邻二酚 在 palladium on activated charcoal 硫酸 、 氢气 、 二异丁基氢化铝 、 potassium carbonate 作用下， 以 四氢呋喃 、 乙酸乙酯 、 丙酮 为溶剂， 反应 30.5h， 生成 8-Methoxy-4,7-dimethyl-chroman-2-ol
  参考文献：
  名称：

  A new approach to the pseudopterosins using an arene alkylation with a γ-methylene-γ-butyrolactone

  摘要：

  A short and practical route to the tricyclic core of an unnatural pseudopterosin diastereoisomer is presented. Key features are an arene alkylation with a gamma -methylene-gamma -butyrolactone, viz. 10 --> 14, and an elaborate reduction sequence 14 --> 17 which both proceed diastereoselectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)02207-3

文献信息

• A new approach to the pseudopterosins using an arene alkylation with a γ-methylene-γ-butyrolactone
  作者：David C Harrowven、Jonathan D Wilden、Melloney J Tyte、Michael B Hursthouse、Simon J Coles

  DOI：10.1016/s0040-4039(00)02207-3

  日期：2001.2

  A short and practical route to the tricyclic core of an unnatural pseudopterosin diastereoisomer is presented. Key features are an arene alkylation with a gamma -methylene-gamma -butyrolactone, viz. 10 --> 14, and an elaborate reduction sequence 14 --> 17 which both proceed diastereoselectively. (C) 2001 Elsevier Science Ltd. All rights reserved.