4,4-Dimethylvaleriansaeure-β-diethylaminoethylester | 58568-09-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4,4-Dimethylvaleriansaeure-β-diethylaminoethylester
• 英文别名: 2-(Diethylamino)ethyl 4,4-dimethylpentanoate
• CAS: 58568-09-5
• 化学式: C₁₃H₂₇NO₂
• 分子量: 229.363
• InChiKey: OLUYFRLJSVIINC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2-二甲基戊酸 、 二乙氨基乙醇 以 xylene 为溶剂， 生成 4,4-Dimethylvaleriansaeure-β-diethylaminoethylester
  参考文献：
  名称：

  Kroening; Schulz; Sprung, Pharmazie, 1975, vol. 30, # 12, p. 765 - 768

  摘要：

  DOI：

文献信息

• Method of encapsulating a nucleic acid in a lipid nanoparticle host
  申请人：Novartis AG

  公开号：US10342761B2

  公开（公告）日：2019-07-09

  Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.

  通过将一种或多种核酸流与一种或多种脂质流相交，生产出粒径均匀较小的封装核酸纳米颗粒。封装核酸纳米粒子包括封装在脂质纳米粒子主体内的核酸。通过在有机溶剂中以高线速度和总有机溶剂浓度低于 33% 的条件下将水性核酸流和脂质流相交，可获得均匀的小颗粒尺寸。
• Lipids and lipid compositions for the delivery of active agents
  申请人：Novartis AG

  公开号：US10426737B2

  公开（公告）日：2019-10-01

  This invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R3, n, p, L1 and L2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.

  本发明提供了一种式（I）化合物或其药学上可接受的盐，其中 R1-R3、n、p、L1 和 L2 在此定义。式（I）化合物及其药学上可接受的盐是一种阳离子脂质，可用于向细胞和组织递送生物活性剂。
• Lipids and Lipid Compositions for the Delivery of Active Agents
  申请人：Brito Luis

  公开号：US20160317458A1

  公开（公告）日：2016-11-03

  This invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R 1 -R 3 , n, p, L 1 and L 2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
• METHOD OF ENCAPSULATING A NUCLEIC ACID IN A LIPID NANOPARTICLE HOST
  申请人：BOWMAN Keith A.

  公开号：US20170196809A1

  公开（公告）日：2017-07-13

  Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by intersecting one or more nucleic acid streams with one or more lipid streams. The encapsulated nucleic acid nanoparticles include a nucleic acid encapsulated within a lipid nanoparticle host. Uniformly small particle sizes are obtained by intersecting an aqueous nucleic acid stream and a stream of lipids in organic solvent at high linear velocities and with total organic solvent concentrations less than 33%.
• Kroening; Schulz; Sprung, Pharmazie, 1975, vol. 30, # 12, p. 765 - 768
  作者：Kroening、Schulz、Sprung

  DOI：——

  日期：——